Scripps Researchers Debunk Theory That Bubonic Plague SNP Confers HIV Resistance | GenomeWeb

Researchers at the Scripps Research Institute have uncovered “strong evidence” that debunks the theory that Caucasians of NorthernEuropean descent — specifically, descendents of people who had been resistant to bubonic plague — may carry a gene mutation that protects against HIV.

The hypothesis under question suggests that the mutation in question, the C-C chemokine receptor 5-32, or CCR5-32, is the same mutation that made individuals resistant to bubonic plague in the late Middle Ages.

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