Scientists Identify Key Protein in Inflammasome Pathway | GenomeWeb

Research led by Giulio Superti-Furga, director of the Center for Molecular Medicine of the Austrian Academy of Sciences, and a postdoc in his lab, Tilmann Bürckstümmer, has found a key protein in the innate immune response pathway called the inflammasome. They discovered AIM2 to be a cytoplasmic sensor of invading DNA, possibly from a virus or pathogen. AIM2 turns out to be the missing link between the activation of interferon and the downstream interleukin signaling cascade, according to their study, which appeared in Nature Immunology.

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