Prevention of miRNA Changes

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Silvio De Flora, a professor in the department of health sciences at the University of Genoa, Italy, and his colleagues report their study of microRNA modulation by chemopreventive agents in non-malignant tissues of rats exposed to environmental cigarette smoke. Using microarray analyses for 484 micro-RNAs and qPCR for a selected miRNA, they found that certain chemopreventive agents modulated ECS-altered p53 function, Ras activation, the NF-kB pathway, and apoptosis, among other processes.

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