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Pairings: Jan 20, 2010

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The Coriell Personalized Medicine Collaborative has formed a new Pharmacogenomics Advisory Group headed by Issam Zineh, associate director for genomics at the Office of Clinical Pharmacology in the US Food and Drug Administration's Center for Drug Evaluation and Research (see related story, this issue).

Other members of the PGx advisory group include:

Amalia Issa, director of the Personalized Medicine and Targeted Therapeutics program at the Abramson Center for the Future of Health;
Andy Godwin, director of the Clinical Molecular Genetics Laboratory at the Fox Chase Cancer Center;
Cal Knowlton, CEO of excelleRx and a member of the board of the American Pharmacists Association Foundation;
Howard McLeod, Fred Eshelman Distinguished Professor of Pharmacogenomics and Individualized Therapy at the University of North Carolina's School of Pharmacy and head of the Pharmacogenetics for Every Nation Initiative;
Michael Ezekowitz, professor of cardiology at the Lankenau Institute for Medical Research;
Michael Murray, director of the General Genetics Clinic at Brigham and Women's Hospital;
Steve Murphy, founder of Helix Health;
Teri Klein, senior research scientist in genetics at Stanford University; and
Wolfgang Sadee, chair of the Department of Pharmacology at Ohio State University.


Laurent Alexandre has been appointed as president and chairman of the board of DNA Vision, a genetic analysis service provider based in Brussels, Belgium.

DNA Vision said that Alexandre will help develop a "new business model" focused on personalized medicine and consumer genomics.

Alexandre is a surgeon and urologist and holds an MBA from HEC Paris, as well as degrees from the Paris Institute of Political Studies and from the École Nationale d'Administration.

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The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.