NY Team Identifies Point Mutation That May Aggravate -- and Prevent -- Heart Disease | GenomeWeb

A team of researchers from Rockefeller University believes that a certain genetic pathway known to contribute to inflammation in coronary vasculature — and thus to myocardial infarction — may protect against the same condition.

The researchers focused on the Nuclear Factor Kappa-B, or NFkB, pathway and had originally set out to identify mechanisms of cardiovascular disease that were not related to one of the primary risk factors for the disease — namely, levels of HDL and LSL cholesterol.

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