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NHLBI Warfarin Trial to Use Trimgen Tests

NEW YORK (GenomeWeb News) — The National Heart Lung and Blood Institute will use TrimGen's eQ-PCR Warfarin Genotyping Kit in a clinical trial designed to find out if a gene-based strategy will benefit patients who are at high risk for warfarin sensitivity.

Sensitivity to the blood-thinning drug can result in a higher risk of thromboembolism and bleeding, and can lead doctors to discontinue the therapy early.

The multi-center study, Clarification of Optimal Anticoagulation through Genetics (COAG), will compare two warfarin dosing approaches, including one group that will receive genotype-guided dosing and another group that will receive dosing using clinical data.

Trimgen said it will contribute the tests used for the study, which will begin in April 2009 and is expected to last until 2012.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.