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New Releases: Jun 17, 2009

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Clarient announced the launch of its new epidermal growth factor receptor mutation test to help physicians select the right treatment for non-small cell lung cancer patients.

The laboratory-developed test analyzes formalin-fixed, paraffin-embedded tissue samples and detects EGFR mutations to help determine which NSCLC patients will respond to tyrosine kinase inhibitor treatments. The RT-PCR assay detects "the most common mutations of the EGFR gene," according to the company.

Test results are available in 10 to 12 days, the company website notes.

Erlotinib (Genentech's Tarceva) and gefitinib (AstraZeneca's Iressa) are two commonly prescribed TKI's in the treatment of NSCLC.

Several other companies market EGFR mutations tests, including Genzyme and DxS.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.