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New Releases: Mar 17, 2010

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Dako said this week that it has gained CE-marking for the use of its HercepTest and HER2 FISH pharmDx tests in metastatic stomach cancer patients who may benefit from Herceptin treatment.

The CE-marking is based on the results of a study of more than 3,700 patients that showed that treatment with Herceptin significantly prolonged the lives of patients with metastatic HER2-positive stomach cancer detected via Dako's tests.

Overall survival for patients with high levels of HER2 in the study was 16 months for patients treated with chemotherapy and Herceptin versus 11.8 months for patients receiving chemotherapy alone.

Approximately one in five of all stomach tumors are HER2-positive, Dako said.

HercepTest is an immunohistochemistry assay used to identify patients with HER2-positive cancer while HER2 FISH pharmDx is a direct fluorescence in situ hybridization assay to quantitatively determine HER2 gene amplification.


Pathway Genomics has released its personal Genetic Health Report, a customized report for its direct-to-consumer genomic service that contains information on more than 70 health conditions, including pharmacogenetics, propensity for complex disease, and carrier status.

The company performs the genetic analysis for its DTC service in an onsite laboratory that is CLIA-certified and licensed in the state of California.

Pathway said that its report provides pharmacogenetic information for Plavix, warfarin, abacavir, carbamazepine, methotrexate, statins, and tamoxifen.

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.