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Nanogen, Invitrogen, Epicenter, Parallabs, Chemagen

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Nanogen has released reagents for research-use-only studies analyzing CYP2C9 and VKORC1, two genes with potential applications in warfarin metabolism and response.
 
The diagnostics developer plans to submit similar reagents for FDA clearance in 2007.
The company said it was spurred by FDA’s forthcoming labeling change for warfarin, recommending CYP2C9 and VKORC1 gene testing before warfarin therapy. The new Nanogen products offer these researchers the ability to investigate the effects of a range of mutations in the CYP2C9 and VKORC1 genes, including the -1639 mutation in VKORC1 and the *2, *3, *5, *6, and *11 alleles of CYP2C9.
 
The reagents can be used to determine genotypes for up to 78 samples.
 

 
Invitrogen has launched its DynaChip HLA antibody analysis system, which uses automated microarray platform to detect antibody reaction to specific HLA antigens. The information generated by the system can be used to select donors for transplants and to monitor post-transplant rejection.  
 
The DynaChip technology evolved through a collaboration between Germany-based array developer Clondiag and Invitrogen. Up to 96 tests can be performed simultaneously, and the technology is available in Europe under a CE mark.
 
DynaChip HLA antibody analysis products are part of a system that also includes the DynaChip Processor, an automated microarray processing instrument, and DynaChip HLA Antibody Analysis Software
 
The company touted the system’s ability to rapidly analyze the results. “With conventional techniques such as ELISA and Luminex single-donor testing, it takes us five days to run the same number of samples that one run of the DynaChip accomplishes,” Donna Phelan, technical supervisor of the HLA laboratory at Barnes-Jewish Hospital, said in a statement.
 

 
Epicenter Biotechnologies has announced the availability ofits TAQurate GREEN Real-Time PCR MasterMix,whichcontains SYBR Green I dye for the detection and quantitation of real-time PCR products.
 
This product also contains the TAQurate Real-Time PCR Enzyme Blend for amplification of difficult templates with high specificity and high reliability. Epicenter said its PCR Enhancer with betaine produces fewer non-specific PCR products by stabilizing the DNA polymerase and reducing pauses and stops in GC-rich or other difficult regions.
 

 
Parallabs announced it has entered into an exclusive distribution agreement with Germany-based Chemagen AG for its Chemagic products. Chemagic automation and reagents perform fast and reliable magnetic bead-based DNA and RNA extraction for sample volumes from 1 µl to 10 ml for blood, tissues, bacteria, food, PCR products, and other samples.  
 

“Advantages of this unique system are fast processing, unmatched sample volume range, and robust chemistry,” Parallabs said in a statement.

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