Mutations in Gene family Affect Response, ADRs in New Colorectal Cancer Regimen | GenomeWeb

Researchers from the Fox Chase Cancer Center in Philadelphia have identified serum genetic markers that may help physicians predict the way a patient with colorectal cancer will respond to irinotecan.

“Our data suggest that variations in genes that help metabolize irinotecan may be useful predictors of how well colorectal cancer patients respond to this drug and how severe side effects will be,” according to Leslie Carlini, a research associate at a Fox Chase lab.

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