Mutation in CYP2D6 May Influence Tamoxifen Efficacy; Some Antidepressants May Play Role | GenomeWeb

The widely used breast cancer drug tamoxifen may be less effective in women with a common mutation in the CYP2D6 gene, according to a new study.

The research also confirmed an earlier study showing that selective serotonin reuptake inhibitors such as Paxil and Zoloft, which block the CYP2D6 enzyme, might also have a negative effect on tamoxifen efficacy.

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