Keck Team spies Gene Transformation Linked to Non-hodgkin s Lymphoma | GenomeWeb

A team of researchers from the University of Southern California have identified a genetic transformation in lymphocytic chromosomes that may cause cells to develop a form of non-Hodgkin’s lymphoma.

Lead author Michael Lieber, a scientist at the Keck School of Medicine and a professor of pathology and biochemistry, said the “fragile” site his team identified is located on the Bcl-2 gene on chromosome 18. Lieber said the Bcl-2 gene, which plays a role in blocking apoptosis, is “the most common fragile site in all of cancer.”

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