Iressa Beats Erbitux in EGFR-Mutant NSCLC; Combination Therapy May Be Way to Go | GenomeWeb

In the Aug. 17 issue of the Journal of the National Cancer Institute, a team of researchers reports that non-small cell lung cancer tumor cells with common mutations respond much better to AstraZeneca's Iressa than to Erbitux, which is manufactured by ImClone Systems and Bristol-Myers Squibb.

The study's results are not entirely surprising, since Iressa binds to the intracellular tyrosine-kinase domain of EGFR, where the mutations are expressed, while Erbitux binds the receptor's extracellular ligand-binding site.

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