International Team Identifies Deletion Linked With High Multiple-Cancer Risk | GenomeWeb

An international team of researchers claim to have identified and genealogically traced a rare deletion mutation linked to hereditary nonpolyposis colon cancer. The mutation predisposes individuals to cancers of the colon, endometrium, and ovaries.

The team said that the deletion in the MSH2 gene “apparently” came to the United States more than 250 years ago, “and it may be responsible for a sizeable portion of certain hereditary cancers in Americans.”

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