Skip to main content
Premium Trial:

Request an Annual Quote

Government of Thailand Establishes Clinical PGx Database for Academia, Dx, Rx Cos

Premium

The government of Thailand is launching a Thailand Center of Excellence for Life Sciences Pharmacogenomics Project to relate health records and personalized medicine information, such as genomic and proteomic data, gathered from hospitals and university research centers throughout the country.

The database, which is up and running, was established through a contract with Oracle. Oracle declined to release financial details.

"One of the reasons why the ministry has pursued and has funded this sort of opportunity is to make certain that there is a commercial potential for this," Tom Jones, Oracle vice president and chief medical officer, told Pharmacogenomics Reporter. Investors or companies wanting access to the data would likely proceed through negotiations with the TCELS and other Thai government agencies, he said.

Representatives of the Thai government could not be contacted before press time.

The project will initially focus on epidemiology, especially that of diseases specific to the region. "It is critical that countries including Thailand, in partnership with the private sector, put in place policies and innovative infrastructures to address public health threats such as SARS and AIDS, Suvit Khunkitti, the Thai minister of information and communication technology, said in a statement.

After its use in straightforward epidemiology, the information in the database would be useful to researchers seeking to understand and capitalize on the relationship between disease response and genomic and other measurable individual variations, said Jones. "What they want to do is prepare for much more sophisticated clinical trials by using the ability to [take patient molecular data] and marry that with clinical profiles of patients," in order to more carefully define cohorts of patients, he said.

The TCELS Pharmacogenomics Project will favor data that have been produced according to predetermined standards, such as the Affymetrix method of standardizing microarray data, said Jones. The database has no projected final size, and could potentially include information gathered from most Thais, he added.

Oracle's system requires patient consent for inclusion into the database, while the government, academic institutions, and hospitals are responsible for authorizing investigators to access the information, Jones said.

Regarding how diagnostic companies interested in the data should relate to TCELS, Jones said, "It would be useful for these centers to have a laundry list of requirements on the part of diagnostic companies as to what sorts of information would be most helpful to them."

The TCELS was established by the Thai government in June 2004.

Filed under

The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.