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Gen-Probe Increases Credit Facility to $250M

NEW YORK (GenomeWeb News) – Gen-Probe has disclosed in a filing with the US Securities and Exchange Commission that it has increased the amount that it can borrow under a recent credit agreement up to $250 million.

The San Diego-based molecular diagnostics firm had inked an agreement in late February to borrow up to $180 million from bank of America under a senior secured revolving credit facility. The firm has borrowed $170 million under that agreement to finance the $132.2 million acquisition of Tepnel Life Sciences and other unspecified corporate purposes.

Gen-Probe expects to complete the Tepnel purchase next month.

The Scan

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.

Mitochondrial Replacement Therapy Embryos Appear Largely Normal in Single-Cell 'Omics Analyses

Embryos produced with spindle transfer-based mitochondrial replacement had delayed demethylation, but typical aneuploidy and transcriptome features in a PLOS Biology study.

Cancer Patients Report Quality of Life Benefits for Immune Checkpoint Inhibitors

Immune checkpoint inhibitor immunotherapy was linked in JAMA Network Open to enhanced quality of life compared to other treatment types in cancer patients.

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.