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GE Healthcare, PerkinElmer, and Cartagen Molecular Systems


GE Healthcare launched Scintillation Proximity Assay (SPA) GPCR Assays offering pre-developed assay conditions for G-protein-coupled receptor-ligand binding studies. GE Healthcare said the pre-validated protocols are for speeding up the work of researchers using GPCR receptor membranes in high-throughput screening environments. The protocols can shave as many as 15 days from the GPCR assay development stage, the company added.

PerkinElmer has 19 new products launching this week. The company said its new offerings fit into three broad categories aimed at enhancing transition to cellular screening, mitigating the ADME/Tox bottleneck, and driving fundamental productivity improvements into the drug discovery and development process. Live cell screening and ADME/Tox includes: CellLux uHTS Cellular Screening System; CellEx Poly-D-lysine coated microplates; Cellular Workstation; and ATP-Lite One-step. Reagent platforms and proprietary consumables include: LANCE cAMP; Easy-Lite Kinase; LANCE Beta-Secretase; new AlphaScreen protocols; OptiPlate 384-HS; Image-Mix Cocktail; and four new GPCR Receptor and Ligands. Automation and detection includes: EnVision “Turbo” AlphaScreen capability; FlexDrop EX; ViewLux uHTS software enhancements; and ELISA Workstation.

Cartagen Molecular Systems announced the launch of its Rapid Homogenization Kit. The kit is a fast and inexpensive method of extracting DNA from plant leaves, the company said. After grinding leaves with an included tool, the homogenate is prepared in a PCR-compatible buffer and spin-filtered to remove excess debris, yielding an amplification-ready sample solution in 10 minutes, the company said.

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The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.