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Epigenomics, J&J, AstraZeneca, Clinical Data, CombiMatrix, Expression Analysis, GlaxoSmithKline, Illumina, Gene Logic

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Epigenomics to Identify, Analyze Biomarkers for J&J Cancer Program
 
Epigenomics will use its differential methylation hybridization chip to help Johnson & Johnson Pharmaceutical Research & Development identify and analyze biomarkers for potential cancer drugs.
 
Terms of the agreement call for Epigenomics to receive an undisclosed upfront payment under the agreement.
 
Additional financial details were not disclosed.
 

 
AstraZeneca Sponsors Fellow to Develop Cancer Assays at UK's DxS
 
AstraZeneca and the University of Manchester are placing a Clinical Research Fellow at DxS to work on a project to identify circulating DNA tumor markers in blood.
 
The focus of the three-year project will initially be to develop assays for genes that show prevalent mutations in cancer. It is supported by AstraZeneca and Cancer Research UK.
 
DxS will help the fellow, unnamed in a press release, to develop the assays using the company's Scorpions and ARMS technologies.
 

 
FDA Asks Clinical Data to Discuss Regulatory Status of Its Tests
 
The US Food and Drug Administration has asked Clinical Data to “discuss the nature and appropriate regulatory status” of the company’s diagnostic tests, Clinical Data said this week.
 
Specifically, the firm and the FDA will discuss whether “any regulatory requirements apply, [and] the least burdensome ways that the company may fulfill them,” Clinical Data said.
 
The company said it plans to meet with the FDA “in the near future.”
 
“The company looks forward to meeting with the FDA and reviewing the regulatory status for all tests conducted on behalf of end-users including FAMILION, its CLIA-certified test for cardiac channelopathies that requires a prescription by healthcare providers,” Clinical Data said in a statement.
 
“Clinical Data notes that while it conducts DNA assays for one nutrigenomic test on behalf of a third party customer, the test is not marketed by Clinical Data and revenue from this test is immaterial” to its business, the company said.
 
“The company believes it is in compliance with all applicable state and federal regulations and will continue to work with the appropriate regulatory agencies to remain so,” Clinical Data said.
 

 
CombiMatrix Adds Aussie Genomic Services Firm to CombiCore Program
 
CombiMatrix has added the Australian Genome Research Facility to its CombiCore program.
 
As part of the agreement, Combi will sell its CustomArrays, CatalogArrays, and array-processing services on a non-exclusive basis to the center, parent Acacia Research said this week.
 
Terms of the deal were not disclosed.
 

 
Glaxo Will Use Expression Analysis' Genotyping Services for PGx Research
 
Expression Analysis last week said it will provide GlaxoSmithKline with microarray-based genotyping services.
 
Under the agreement, Expression Analysis will support GSK’s pharmacogenomic studies in clinical trials.
Financial details were not disclosed.
 

 
Illumina Expands Genotyping Deal With GlaxoSmithKline
 
Illumina has expanded the scope of its multi-year genotyping services agreement with GlaxoSmithKline, Illumina said last week.
 
Under the new agreement, Illumina will use its Sentrix HumanHap550 BeadChips for a series of whole-genome association studies.
 
As the first study, Illumina will genotype a collection of 2,000 case and control DNA samples provided by GSK for an undisclosed disease.
Financial details were not disclosed.
 

 
Gene Logic's Q2 Revenue Falls 44 Percent on Weak Genomics Results
 
Gene Logic last week reported that total revenues for the second quarter declined nearly 44 percent due to weak performance in its genomics segment.
 
Receipts for the three months ended June 30 declined to $11 million from $20 million year over year.
 
The genomics division reported revenues of $4.7 million, a 67-percent decline over the prior year period. Declining subscription revenue, database license sales that failed to materialize, and slower-than-expected sales growth for microarray data-generation and -analysis services were blamed for the slide.
 
Gene Logic hired a strategy-consulting firm to review its business strategy, the company said. The review results will be released by Sept. 22.
 
As GenomeWeb News reported earlier this week, the company began restructuring its genomics division by announcing plans to lay off approximately 80 employees. The lay-offs are effective as of Oct. 5 and will cost $1.8 million in severance.
 
Gene Logic said it expects the lay-offs to reduce annual salary and fringe benefits costs by approximately $8 million.
 
R&D costs in the secnd quarter soared 84 percent to $2.5 million from $1.4 million from the comparable quarter a year ago.
 
Gene Logic said net loss quadrupled to $11.3 million from $2.6 million during the comparable period last year.
 
The company withdrew its financial guidance for 2006 and 2007 in June.
 
Gene Logic said it had around $24.8 million in cash and cash equivalents as of June 30.

Filed under

The Scan

Booster for At-Risk

The New York Times reports that the US Food and Drug Administration has authorized a third dose of the Pfizer-BioNTech SARS-CoV-2 vaccine for people over 65 or at increased risk.

Preprints OK to Mention Again

Nature News reports the Australian Research Council has changed its new policy and now allows preprints to be cited in grant applications.

Hundreds of Millions More to Share

The US plans to purchase and donate 500 million additional SARS-CoV-2 vaccine doses, according to the Washington Post.

Nature Papers Examine Molecular Program Differences Influencing Neural Cells, Population History of Polynesia

In Nature this week: changes in molecular program during embryonic development leads to different neural cell types, and more.