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Using biomarkers to enrich studies too early in the drug-development process, especially for cancer drugs, can prematurely narrow the patient population and lead to drug failure, cautioned Mark Ratain, professor of medicine at the University of Chicago.
 
“Should biomarkers be used for eligibility criteria in Phase I/II studies? My answer is, ‘No,’” Ratain said during a presentation at the American Association for Cancer Research’s annual meeting in Los Angeles last month.
 

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