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Cellomics, Applied Biosystems, Quantum Dot, SC BioSciences, Matsushita Electric Industrial, Matsushita Kotobuki Electronics


Cellomics has released a trio of new BioApplication software modules: Kinetic Molecular Translocation, Morphology, and Cell Health Profiling, which are designed to be used with Cellomics’ HCS Platform.

The Kinetic Molecular Translocation BioApplication is an application for measuring and reporting on the kinetics of protein translocation. The tool performs measurements on cells to “assess the relative distribution of fluorescently labeled targets between the cytoplasm and the nucleus,” Cellomics said. Its main use is “detecting the activity of compounds that alter the normal distribution of fluorescent protein biosensors in the cell, as well as detecting inhibitors of translocation processes.”

The Cell Health Profiling BioApplication enables researchers to design and validate their own assays to “measure multiple parameters related to cytotoxicity and/or apoptosis.” The Morphology Explorer BioApplication, meantime, is an algorithm that measures the size, shape, and texture of cells and multicellular assemblages. It can screen targets such as cytoskeletal rearrangement and colony formation, Cellomics said in a statement.

Applied Biosystems has launched a new DNA polymerase that enables Mg2+-activated, single-enzyme RT-PCR experiments to be performed in a single-tube-reaction. The product, called the GeneAmp AccuRT RNA PCR enzyme, allows researchers to perform reverse transcription and PCR amplification at elevated temperatures, which “helps to remove secondary structures from the template, and facilitates highly stringent … annealing of gene-specific primers,” ABI said in a statement.

The company has also introduced the GeneAmp AccuRT Hot Start RNA PCR Kit for hot-start reactions. This is an aptamer-based system that provides hot-start capability both for reverse transcription and PCR.

Quantum Dot, SC BioSciences, Matsushita Electric Industrial, and Matsushita Kotobuki Electronics have the launched the first product from their newly penned partnership. The product is a high-throughput optical scanner, called the Mosaic Scanner, with an initial application in gene-expression analysis. The groups plan future applications in genotyping, protein analysis, and cell analysis are planned.

The Mosaic System comprises the Mosaic Scanner, developed and manufactured by MKE and MEI, and Qdot and Qbead kits and reagents, developed by Quantum Dot. Terms of the collaboration, announced in August but originally uncovered by SNPtech Reporter in June [See SNPtech Reporter article, 6/20/2003], call for Quantum Dot to market and sell the products worldwide. However, SC BioSciences holds exclusive sales and marketing rights in Japan, Quantum Dot said in a statement.

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