A targeted-medicine hopeful is in trouble.

After reviewing recent data showing no survival benefit for patients taking the cancer drug Iressa, the US Food and Drug Administration this week urged current consumers of the drug to see their doctors and consider changing prescriptions, a development that may spell the end of the drug unless responders can be reliably identified. The company’s manufacturer, AstraZeneca, is currently discussing the drug’s fate with the FDA.

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The US Food and Drug Administration has approved Kite Pharmaceuticals' CAR T-cell therapy for large B-cell lymphomas, the New York Times reports.

Kaiser Health News reports that gene therapies could cost more than a million dollars.

Worcester Polytechnic Institute researchers have received a grant to combine biology and computer science for high school students.

In Nature this week: variants associated with obsessive-compulsive disorder, review of key CRISPR enzymes, and more.