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Affymetrix, ParAllele Biosciences, Roche, Epigenomics, Applied DNA Sciences

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Affy Supplies ParAllele with GeneChips

Affymetrix will supply ParAllele Biosciences with GeneChip microarrays to use in its SNP-genotyping technology, the companies said this week.

Under the three-year agreement, Affymetrix will provide ParAllele, of South San Francisco, Calif., with custom and catalog tag arrays to use with its commercial genotyping service business and in its collaborations with pharmaceutical companies. Parallele will also work to design SNP assays based on the Affy platform.


Roche, Epigenomics Pen Cancer DX Deal

Over the next three years, Roche will use DNA-methylation technologies developed by Epigenomics to develop molecular-diagnostic and pharmacogenomic assays for a variety of cancers.

Terms of the agreement, announced earlier this week, call for Roche to pay Epigenomics €4 million, or roughly $4.25 million. The deal also includes R&D funding, milestone payments, and royalties that could total €100 million, the partners said.

The products to be developed include diagnostic and prognostic tools for colon, breast, and prostate cancer, as well as pharmacogenomics tests that can predict a patient's response to cancer drugs.

Roche will use its PCR and microarray technology in the assays. The methylation technologies involve measuring the differences in DNA methylation between diseased and healthy conditions. Methylation, the phenomenon wherein a methyl group is attached to the cytosine base on DNA, is a major mechanism of control for gene expression.


Applied DNA Sciences Opens Office in NC

Applied DNA Sciences has opened an office in Henderson, NC. The new facility will allow the company to market its embedded-DNA authentication products to the textile, pharmaceutical, as well as homeland security agencies located on the east coast of the United States.

The company’s technology was devised to impact the more than $350 billion of counterfeit products sold annually around the world. The technology is being marketed via direct sales, channel partners, resellers, and certain undisclosed strategic alliances.

Applied DNA’s technology is designed to “mark” raw textile materials and finished goods. It can also identify both the country of origin as well as the specific factories where a garment and/or its components were produced.

 

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The Scan

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Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.