tamoxifen Sequencing-Based Assessment of CYP2D6 Could Improve Prediction of Drug Response Premium Researchers have developed a computational method that considers uncommon CYP2D6 variants to assess patient-specific metabolism of tamoxifen and other drugs. Biotheranostics' Breast Cancer Index Included in Latest NCCN Guidelines The expert body now recognizes the test's ability to predict whether early-stage breast cancer patients will benefit from extended, adjuvant endocrine therapy. OncotypeDX Score May Give Valuable Info on Breast Cancer Locoregional Recurrence Such prognostic information could aid clinicians in making decisions about radiotherapy for postmenopausal women with breast cancer. Tumor Heterozygosity Loss May Explain Failure of Studies to Link CYP2D6, Tamoxifen Benefit Premium Data shows CYP2D6 testing in breast tumor tissue can be inaccurate due to loss of heterozygosity, and may have obscured the connection between genotype and tamoxifen response in previous trials. Breaking News Guardant Health Files Motions to Dismiss, Change Venue in Illumina Patent Lawsuit In Brief This Week: SQI Diagnostics, T2 Biosystems, Enhanc3D, QuidelOrtho, More Illumina, Precision Health Research Singapore Partner for 100K Genomes Population Study 23andMe Fiscal Q4 Revenues Increase 14 Percent Local Coverage Determinations Roundup: Castle Bio, SkylineDx Ancient Genome Sequence Provides Look at Ancestry for Individual Who Perished at Pompeii The Scan Billion-Dollar Diversity Initiative The Howard Hughes Medical Institute is now accepting applications for its new $1.5 billion initiative to boost the diversity of the scientific workforce. Biotech Co-Founder Arrested A co-founder of a Los Angeles-based biotech company has been arrested in connection with a murder-for-hire scheme, according to Endpoint News. Return of the Tasmanian Tiger The Washington Post reports that a team in Australia is working to bring the thylacine back from extinction. Nature Papers on Genome of Individual From Pompeii, CircRNA Study Best Practices, More In Nature this week: first sequenced genome of a person from Pompeii, best practice guidelines for circRNA studies, and more.