olaparib Lynparza Benefit in Early BRCA-Mutated Breast Cancer Reignites Universal Genetic Testing Discussion Premium The OlympiA trial showed a disease-free survival benefit with adjuvant PARP inhibitor therapy for early-stage, BRCA1/2-mutated, HER2-negative breast cancer patients. Uterine Leiomyosarcoma Sequences Point to Potentially Targetable Somatic Mutations Using genome, exome, or transcriptome sequences from dozens of uterine leiomyosarcoma samples, researchers found alterations that may respond to existing targetable treatments. Myriad Genetics Expands MyChoice CDx Access Through Partnerships in Europe, China A deal with Burning Rock will allow the test to be used in trials and clinics in China, and Myriad will license its technology to French and German pathology labs. FDA Approves Foundation Medicine Liquid Biopsy Test as CDx for Lynparza The test will use a blood-based biopsy to detect patients with BRCA1, BRCA2, and/or ATM alterations in metastatic castration-resistant prostate cancer. Medicare to Cover Myriad Genetics' BRACAnalysis for FDA-Approved CDx Indications In a local coverage article, Medicare contractors in the MolDx program added prostate cancer to the covered indications for the test. Jul 14, 2020 Genetic Alterations in Cyclin-Dependent Kinases Highlight Potential Cancer Treatment Approach May 20, 2020 FDA Approves Lynparza With Myriad, Foundation Med CDx Tests in HRR-Mutated Prostate Cancer May 11, 2020 FDA Approves Lynparza/Avastin With Myriad Genetics CDx for Platinum-Sensitive Ovarian Cancer Mar 30, 2020 Myriad Genetics Seeks Japan Approval for Advanced Pancreatic, Prostate Cancer Companion Diagnostic Feb 11, 2020 Myriad Files sPMA With FDA for Test to ID Best Responders to Lynparza, Avastin Combination Jan 21, 2020 Myriad Genetics Files for FDA Approval of BRACAnalysis CDx for Lynparza in Prostate Cancer Dec 30, 2019 FDA Approves AstraZeneca's Lynparza, Myriad Genetics' CDx for BRCA-Positive Pancreatic Cancer Aug 7, 2019 Personalis to Provide Immunogenomic Profiling for University of New Mexico Ovarian Cancer Study Aug 7, 2019 Myriad Genetics Seeking Additional FDA Approval for BRACAnalysis CDx Jul 1, 2019 FDA Approves Foundation Medicine CDx Test for Lynparza Jun 19, 2019 AstraZeneca, Merck's Lynparza, Myriad Genetics' BRCA Test Approved in Japan Jun 6, 2019 TAPUR Study Investigators Report First Positive Findings, Pursuing Tissue-Agnostic Cohorts Premium Jun 3, 2019 Lynparza Delays Progression in Metastatic Pancreatic Cancer Patients With Germline BRCA Mutations Premium May 16, 2019 NCI Pediatric MATCH Trial Interim Data Shows 24 Percent of Patients Eligible for Targeted Therapy Premium Apr 4, 2019 Myriad Genetics, AstraZeneca, Merck Expand BRCA CDx Collaboration Apr 2, 2019 Treatment With Less Toxic Rubraca in Molecularly-Defined Pancreatic Cancer Subset Proposed at AACR Premium Dec 19, 2018 FDA Approves Myriad Genetics' BRACAnalysis CDx With Lynparza in Earlier Ovarian Cancer Setting Apr 2, 2018 Japanese Regulators Approve Myriad Genetics' BRACAnalysis Test Jan 12, 2018 FDA Approves Myriad CDx With AstraZeneca Drug for BRCA-Mutated Breast Cancer Patients Oct 18, 2017 FDA Accepts Myriad BRACAnalysis CDx Supplementary PMA for Lynparza in Breast Cancer Indication Load More Breaking News Lunaphore Technologies, University of Bern Partner on Colorectal Cancer Study People in the News: New Appointments at Biocept, Novacyt, Centogene, Illumina, More In Brief This Week: Sophia Genetics, Twist Bioscience, Dante Labs, MGI, Codex DNA, More New Products Posted to GenomeWeb: SpeeDx, Bio-Techne, NuProbe, More DiaSorin Q2 Revenues Rise 20 Percent on SARS-CoV-2 Testing Demand Cepheid Gets $28M From BARDA for SARS-CoV-2 Tests The Scan Interfering With Invasive Mussels The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels. Participation Analysis A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports. Right Whales' Decline A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC. Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.