nivolumab UK Researchers Show Cytotoxic T-Cell Level Predicts Melanoma Immunotherapy Response A Science Immunology paper details how patients with more cytotoxic effector T cells in peripheral blood at baseline respond better to checkpoint inhibitors. Sophia Genetics, Spanish Lung Cancer Group Team up to Predict Lung Cancer Treatment Response The firm and cancer centers will use radiomics, clinical, biologic, and genomics data to predict responses to neoadjuvant nivolumab plus chemo in NSCLC. OmniSeq, UPMC Partner on Immunotherapy Trial Matching for Head and Neck Cancer The Phase II trial will use OmniSeq's RNA-seq assay to determine whether patients should be treated with one of two agents combined with BMS' nivolumab. BostonGene, Thomas Jefferson University Partner on Head, Neck Cancer Research The partners will apply whole-exome and whole-transcriptome analysis to evaluate two existing drugs for squamous cell carcinoma treatment. T Cell Receptor Repertoire Linked to Anti-PD-1 Therapy Response in Hodgkin Lymphoma Therapy was most effective in patients with a diverse baseline repertoire of T cell receptors and an associated expansion of singleton clones during treatment. Jan 22, 2020 B Cell Gene Expression Profiling May Enable Cancer Immunotherapy CDx Test Premium Jan 14, 2020 Immunotherapy Response Prediction Improves With TMB Correction, Other Markers Premium Dec 9, 2019 PAK4 Inhibition Increases Anti-PD-1 Response in Mouse Models Prompting Phase I Trial Breaking News CDC Awards $22M to Combat Antimicrobial Resistance, Infectious Diseases Pan-Cancer Analysis Reveals Unique Features in Tumors From Younger People Breast Cancer Therapy Response Predicted by Multiomic Machine Learning Model Cytena Inks China Distribution Deal for Single-Cell Isolators Freenome Raises $300M in Series D Financing More Than Dozen Genetic Loci Linked to Amyotrophic Lateral Sclerosis Risk The Scan Less Than Half An effort to reproduce key findings from high-profile preclinical cancer studies finds less than half could be replicated, according to the Scientist. Still Some SARS-CoV-2 Sequencing Holes The Wall Street Journal reports that viral genomic surveillance has improved in the US, though says there are still gaps. Avoiding Passing Them On People with known disease-linked genetic variants are turning to in vitro fertilization so as to not pass those variants to their children, the Washington Post says. PNAS Papers on Long Cell-Free DNA in Maternal Plasma, Genetic Propensity for Voting In PNAS this week: long, cell-free DNA of maternal and fetal origins identified in maternal plasma, and more.