dabrafenib Circulating Tumor DNA Provides Prognostic Clues in Advanced BRAF-Mutated Melanoma Cases Using the BRAF-V600 tumor mutation as a marker, investigators identified pre-treatment and on-treatment ties between ctDNA and patient outcomes. Colorectal Cancers Dial up Mutability in Response to Targeted Treatments A new study suggests that colorectal cancers increase their mutation rate to dodge treatment in a manner that mirrors microbial resistance mechanisms. After Approval of Next-Gen Sequencing CDx Panel, Thermo Fisher Seeks Rapid Expansion of Indications Premium The initial FDA approval of Thermo Fisher's NGS panel test for personalizing cancer treatment may allow rapid expansion to new indications. Thermo Fisher Next-Gen Sequencing Panel Wins FDA Approval as Companion Test The so-called universal CDx approved by the FDA can gauge alterations across multiple genes associated with response to three lung cancer treatments. Dana Farber Data Supports Genomics as Standard of Care for Pediatric Brain Cancer Premium The study showed that targeted sequencing was feasible, identified many clinically relevant alterations, and directed effective targeted therapy in several cases. Aug 8, 2016 BRAF Inhibitor Resistance Mutations Identified Breaking News GenomeWeb Index Falls 6 Percent in November as Emergence of Omicron Spooks Markets Sequencing-Based MRD Detection in Bone Marrow May Predict ALL Relapse After CAR T-Cell Therapy Metabolomic Study Links 13 Metabolites to Coronary Heart Disease Risk Among African Americans Illumina Wins $8M Jury Verdict in BGI Patent Infringement Suit, Loses Patent Caris Life Sciences Facing FTC Lawsuit After Resisting Subpoena in Illumina, Grail Antitrust Case Biodesix, Spesana Partner to Improve Workflows for Lung Cancer Molecular Diagnostic Tests The Scan Panel Votes for COVID-19 Pill A US Food and Drug Administration panel has voted to support the emergency use authorization of an antiviral pill for COVID-19 from Merck and Ridgeback Biotherapeutics, CNN says. But Not Harm New Scientist reports that UK bioethicists say that though gene editing may improve food production, it should not harm livestock welfare. Effectiveness Drop Anticipated Moderna's Stéphane Bancel predicts that that current SARS-CoV-2 vaccines may be less effective against the Omicron variant, the Financial Times reports. Cell Studies of Human Chromatin Accessibility, SARS-CoV-2 Variants, Cell Signaling Networks In Cell this week: chromatin accessibility maps of adult human tissues, modeling to track SARS-CoV-2 variants of concern, and more.