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Drug Discovery & Development

News on drug screening, clinical trials, companion diagnostics, immunotherapy, & personalized therapies in genetics, genomics, and molecular diagnostics.

New Mouse Models for Late-Onset Alzheimer's Disease May Advance Biomarker, Drug Discovery

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Researchers used CRISPR to engineer mice that have multiple genetic variants associated with late-onset AD to facilitate research into biomarkers and treatments.

GSK, 23andMe Gamble on Personalized Drug Discovery With Exclusive Deal

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With a $300 million investment in 23andMe, GSK pivots toward personalized medicine again, while the consumer genomics firm hitches its drug development ambitions to GSK.

23andMe, GSK Ink Exclusive Drug Target Discovery Pact

The companies will initially contribute equally to funding the collaboration and will share in future proceeds from drugs developed within the partnership.

Strata Oncology to Aid Puma Biotech in Recruiting for Neratinib HER2 Basket Study

Strata will refer individuals with HER-2 mutations identified through its screening trial for consideration as subjects in Puma's SUMMIT trial.

Predicine, Kintor Pharmaceuticals Partner on Clinical Trials, CDx

Under the new collaboration, Predicine will use its GeneRADAR technology to aid Kintor in the development and advancement of novel drugs.

The Scan

An RNAi Approval

The US Food and Drug Administration has approved Alnylam's RNAi-based therapy Onpattro, according to Stat News.

Keep It Going

Harvard Medical School's Seth Cassel and Cigall Kadoch argue in a Baltimore Sun op-ed that the recent TAILORx trial shows the potential of genomic-based medicine.

Stop It There

Researchers in the UK are working on using gene drives to control malaria-carrying mosquitoes, the Telegraph reports.

This Week in PLOS

In PLOS this week: genetic architecture mediating gene expression, metabolomic patterns in multiple myeloma, and more.

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