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These alterations, which can include hypermethylation of the H19 locus, can crop up during kidney development.
Though some experts prefer the comprehensive nature of whole-genome sequencing, others find whole-exome sequencing or targeted exome panels to be more useful.
By sequencing 72,501 individual kidney cells, researchers saw some shared transcriptional patterns in kidney cancers and developing or adult kidneys.
In PLOS this week: links between gut microbiome and colorectal cancer mutations, targeted sequencing uncovers genetic susceptibilities to epilepsy in Koreans, and more.
Name: Peter Papenhausen
Title: National Director of Cytogenetics, Laboratory Corporation of America
NEW YORK (GenomeWeb News) – Two new loci have been linked to elevated risk for a childhood embryonal kidney cancer called Wilms tumor, according to a study appearing online yesterday in Nature Genetics.
Using custom microarrays and bisulfite sequencing, researchers have garnered evidence of extensive shifts and variability in methylation patterns in the genomes of several types of cancers.
Biovista will use its Clinical Outcomes Search Space platform to identify new treatments as part of the EU's "p-medicine" project.
The US Food and Drug Administration is to announce stricter standards for emergency authorizations of SARS-CoV-2 vaccines, reports the Washington Post.
The Associated Press reports Johnson & Johnson is starting a late-stage clinical trial of its candidate SARS-CoV-2 vaccine.
Bloomberg reports the budget of Operation Warp Speed is actually $18 billion, higher than the number typically cited.
In Genome Research this week: genomic analysis reveals role of super-spreaders in SARS-CoV-2, epigenetic drivers of cancer, and more.