vascular disease

Researchers identified somatic KRAS mutations in affected tissue from more than 60 percent of people with sporadic arteriovenous malformations of the brain.

Tapping into genetic variation in the CETP gene, investigators explored blood lipid and disease effects of high-density cholesterol changes.

With new gene sequencing panels, investigators made firm or possible diagnoses in almost one-third of undiagnosed autoinflammation and vasculitis cases.

This Week in PLOS

In PLOS this week: PHACTR1 variant linked to fibromuscular dysplasia, harbor porpoise population study, and more.

A team of researchers from  Brigham and Women's Hospital and Harvard Medical School found that the two proteins appear to have opposing effects.

According to the company, the study, which was presented at the 42nd Annual Meeting on Women's Cancer of the Society of Gynecological Oncologists, examined more than 20 candidate biomarkers, identifying three potentially useful analytes.

The NHGRI-led program has seen its first major success by identifying the genetic basis for a rare and debilitating vascular disorder.

NHLBI in late January put out an RFP for the program, which calls for researchers to develop proteomics technologies and apply them to solve clinical puzzles. It is set to begin early next year, shortly after its current two major proteomics initiatives expire.

IP Update

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USPTO Publishes Six RNAi-Related Patent Applications

Cancer researcher Alan Rabson has died at 92, the New York Times reports.

As the National Guideline Clearinghouse goes dark, the ECRI Institute says it will pick up the slack.

In Genome Research this week: sequencing method examines proteins parasite uses to evade immune system, L1 insertions in cancer, and more.

The Atlantic reports on private Facebook support groups for people who receive unexpected parentage results from direct-to-consumer genetic tests.