vascular disease
Brain Vascular Malformation Insights Gleaned From Single-Cell Atlas
With single-cell RNA sequencing, researchers characterized expression and cell type shifts in brain vascular samples from individuals with or without brain arteriovenous malformations.
KRAS Mutations Revealed in Rare Vascular Brain Condition
Researchers identified somatic KRAS mutations in affected tissue from more than 60 percent of people with sporadic arteriovenous malformations of the brain.
HDL Cholesterol Boost Alone Does Not Reduce Cardiovascular Disease Risk, Genetic Study Suggests
Tapping into genetic variation in the CETP gene, investigators explored blood lipid and disease effects of high-density cholesterol changes.
Panel Sequencing Leads to Pathogenic Mutations in Autoinflammatory Cases
With new gene sequencing panels, investigators made firm or possible diagnoses in almost one-third of undiagnosed autoinflammation and vasculitis cases.
Proteomic Analysis Uncovers Role For PARP9, PARP14 in Macrophage Activation
A team of researchers from Brigham and Women's Hospital and Harvard Medical School found that the two proteins appear to have opposing effects.