ulcerative colitis
Inflammatory Bowel Disease Genetic Risk Architecture Appears Distinct in African Americans
Using whole-genome sequence data for thousands of African American individuals, researchers teased out ancestry effects on polygenic risk of the conditions.
Sano Genetics, Patients Know Best, BenevolentAI, C4X Discovery Form Ulcerative Colitis Alliance
The British companies will collaborate on a database to support ulcerative colitis research and identify new drug targets for the disease.
IBD Polygenic Risk Scores Improved With Data From Multiple Ancestral Backgrounds
The researchers also examined the contribution of rare variants to inflammatory bowel disease to find a potential targetable pathway.
Single-Cell Analysis Reveals Ulcerative Colitis Tissue, Immune Features
With single-cell transcriptomic, T cell receptor, and B cell receptor data, researchers tracked immune shifts in tissue and peripheral blood samples from ulcerative colitis patients.
Inflammatory Bowel Disease Study Points to Role For Somatic Colon Mutations
Analyzing genome sequences from dozens of cases and controls, researchers saw an IBD-associated jump in somatic mutations in colonic crypt samples.