ulcerative colitis
Ulcerative Colitis Study Analyzes Gene Expression to Measure Risk of Progression to Surgery
RNA data helped researchers develop a predicted polygenic transcriptional risk score that identified UC patients at fivefold elevated risk of colectomy.
Inflammatory Bowel Disease Genetic Risk Architecture Appears Distinct in African Americans
Using whole-genome sequence data for thousands of African American individuals, researchers teased out ancestry effects on polygenic risk of the conditions.
Sano Genetics, Patients Know Best, BenevolentAI, C4X Discovery Form Ulcerative Colitis Alliance
The British companies will collaborate on a database to support ulcerative colitis research and identify new drug targets for the disease.
IBD Polygenic Risk Scores Improved With Data From Multiple Ancestral Backgrounds
The researchers also examined the contribution of rare variants to inflammatory bowel disease to find a potential targetable pathway.
Single-Cell Analysis Reveals Ulcerative Colitis Tissue, Immune Features
With single-cell transcriptomic, T cell receptor, and B cell receptor data, researchers tracked immune shifts in tissue and peripheral blood samples from ulcerative colitis patients.