An international research team has mined tuberculosis whole-genome datasets to identify new mechanisms of resistance to highly toxic drugs.
The study describes an RNA expression signature unique to people who are likely to develop an active TB infection, which could help prevent it.
In PLOS this week: sites in dog genome under selection during early domestication, tuberculosis transmission patterns, and more.
A genome-wide association study of HIV-infected individuals in Uganda and Tanzania led to a chromosome 5 locus that may protect against active TB infection.
Researchers used existing expression data for thousands of individuals, including those with active and latent TB, to find a three-gene signature for active infection.
In PLOS this week: researchers explore the transfer of host genetic material into viruses, and more.
In Nucleic Acids Research this week: methylation patterns in Mycobacterium tuberculosis, statistical approach to uncover alternative splicing patterns, and more.
The Collaborative African Genomics Network recently finished its second year of grant funding, hitting many of its milestones, and is already digging into the work for their third year.
The firm signed a memorandum of understanding with the agency and is expected to detail the terms of the cooperation in a subsequent collaborative agreement.
Researchers in the UK have developed a faster way to gauge antibiotic resistance from bacterial genomes.
Bioethicists disagree with a research team's decision to allow the return of risk results for adult-onset conditions from a newborn sequencing project, according to Reuters.
Alterations to particular gene may enable the Quechua of Peru to better tolerate high-altitude life, Ars Technica reports.
Nature News reports that additional South Korean researchers have included the names of children on scientific papers when they did not contribute to the work.
In PLOS this week: statistical approach to prioritize rare variant searches, gene expression alterations in chronic obstructive pulmonary disease, and more.