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Trace Their Path

Genome sequencing is a new tool in the fight against drug-resistant bacteria, writes Lara Marks at The Conversation.

The funding comes as part of the agency's Advanced Molecular Detection initiative, which is using the technologies to help address infectious disease outbreaks.

In PLOS this week: mitochondrial DNA dynamics, tuberculosis transmission patterns in Malawi, and more.

The project aims to use omics and systems biology approaches to characterize strains of tuberculosis with an eye toward identifying therapeutic targets.

Researchers have identified mutations in the RORC gene that produce inborn errors of immunity affecting both interleukin-17 and interferon-gamma immune pathways.

In PNAS this week: human cytomegalovirus diversity, patterns of homologous recombination in E. coli, and more.

Intended for diagnosing active pulmonary tuberculosis, the test will use Cere's Nanotrap reagents for enriching target analytes for downstream analysis.

In PLOS this week: genomic analysis of Malaysian tuberculosis strain, database of bat genomes, and more.

Researchers combined genome sequences and drug susceptibility data for thousands of Mycobacterium tuberculosis isolates to find mutations for predicting resistance.

The gift is from a group of more than 20 philanthropists and will be used to develop a rapid diagnostic test for drug-resistant TB. 

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In PLOS this week: transcriptomic and genomic analysis of prostate cancer by ancestry, genes linked to liver function in Korean cohort, and more.

British Columbia is incorporating genomics into its tracking of the ongoing COVID-19 outbreak, Business in Vancouver reports.

An analysis by the Personalized Medicine Coalition finds that about a quarter of new drugs approved in 2019 by the US Food and Drug Administration were personalized medicines.

The governor of New York has proposed a five-year plan to study the genomes of people with or who are at high risk of developing Alzheimer's disease.