Researchers sequenced and analyzed 169 Mycobacterium tuberculosis strains from people with and without HIV infections.
In Nucleic Acids Research this week: isomiR-based cancer classifier, map of VjbR binding in Brucella, and more.
In PLOS this week: mitochondrial mutation linked to tubulointerstitial kidney disease, asthma protection variant, and more.
The research team evaluated the Illumina MiSeq and Ion PGM sequencing platforms, as well as the bioinformatics pipelines TBProfiler and Mykrobe predictor.
In PLOS this week: genetic evolution of Mycobacterium tuberculosis, mutation rate variation patterns in people, and more.
The evidence-based guidelines for testing individuals at risk of latent or active TB infection include recommendations on interferon-gamma release and molecular assays.
The company has identified markers of latent disease that it is now investigating to see if they could be useful for predicting progression to active infection.
The funding will be used to further develop a 20-minute tuberculosis detection assay and drug susceptibility test using the firm's handheld Q-POC microfluidic PCR system.
In PNAS this week: effect of structural variants on gene expression in cancer, Mycobacterium tuberculosis population genomics study, and more.
Cepheid noted that the cartridge is not currently part of its five-year commercial plan, but the firm is in discussions with outside parties to push development forward.
Harold Varmus, a former NIH director, says that proposed reductions to the agency's budget are worrisome.
The Genome 10K project is to sequence about 10,000 vertebrate genomes, including ones of endangered species, Digital Trends reports.
The new Coalition to Save NIH Funding aims to educate lawmakers and the public on the significance of biomedical research.
In PLOS this week: analysis of viral sequences from human blood samples, gut microbiomes of heart failure patients, and more.