transthyretin-mediated amyloidosis Improved Cytosine Base Editing Tech Eliminates Problem of Undesired Bystander Mutations The percentage of perfectly modified alleles using the new base editor is more than 6,000-fold for disease correction compared with the current BE4max editor. Alnylam Publishes Phase I Data on ATTR Drugs Premium Alnylam Pharmaceuticals and collaborators this week published data from phase I trials of the siRNA-based transthyretin amyloidosis drugs ALN-TTR01 and ALN-TTR02 in the New England Journal of Medicine. Alnylam Initiates Phase I Trial of Second-Gen TTR Amyloidosis Drug Premium Alnylam Pharmaceuticals this week said that it has begun dosing patients in a phase I study of its siRNA-based transthyretin-mediated amyloidosis treatment ALN-TTR02. Alnylam Focuses on Two Lead Programs, Won't Advance Others without Partners Premium By Doug Macron Alnylam Adding Patients to ATTR Trial, Conducting Interim Analysis of RSV Data Premium Alnylam also released its first-quarter financial results, reporting higher losses and lower revenues. Jan 27, 2011 Alnylam's TTR Amyloidosis Drug Receives Orphan Drug Designation in Europe Premium Jan 6, 2011 Unveiling New Strategy, Alnylam Aims to Debut Five Clinical Candidates by 2015 Premium Breaking News Sequencing Study Uncovers MERS-Related Coronavirus in Swiss Bats Angstrom Bio Raises $3M in Private Financing Eagle Biosciences, Genetic Analysis Ink Distribution Agreement for Gut Microbiota Test Centogene Q1 Revenues Grow More Than Fivefold Driven by COVID-19 Testing Epizyme Partnering With Quest Diagnostics for Lymphoma Mutation Testing Enzo Biochem, CLX Health Partner to Support COVID-19 Testing for International Travel The Scan CDC Calls Delta "Variant of Concern" CNN reports the US Centers for Disease Control and Prevention now considers the Delta variant of SARS-CoV-2 to be a "variant of concern." From FDA to Venture Capital Former FDA Commissioner Stephen Hahn is taking a position at a venture capital firm, leading some ethicists to raise eyebrows, according to the Washington Post. Consent Questions Nature News writes that there are questions whether informed consent was obtained for some submissions to a database of Y-chromosome profiles. Cell Studies on Multimodal Single-Cell Analysis, Coronaviruses in Bats, Urban Microbiomes In Cell this week: approach to analyze multimodal single-cell genomic data, analysis of bat coronaviruses, and more.