Close Menu

Stevens-Johnson syndrome

Pharmigene said last week that 50 hospitals in Taiwan will now administer its test for HLA-B*1502, which is a marker for increased risk of adverse events in Asian populations treated with the anti-seizure drug carbamazepine.

The US Food and Drug Administration in 2007 updated the label for carbamazepine to recommend that patients of Asian ancestry taking the drug be tested for the HLA-B*1502 marker. While one NEJM study published this week supports this practice, a second study suggests that the boxed warning be expanded to include a new allele for the European population.

Nine members of the HMO Research Network "will use detailed clinical profiles to search for potential subjects to enroll into … serious adverse events research projects using their electronic medical record databases," iSAEC said in a statement.

The Mayo Clinic will develop tests to detect for the presence of alleles that increase the risk for developing the potentially deadly skin disease if certain drugs are taken.

For the first year of the SAEC-HMORN collaboration, each HMO will sift through the clinical profile of its members in the network's database and identify potential participants for future gene-association studies.

The data, analyzed from biological samples donated by GlaxoSmithKline, is available on SAEC's website for free, and the group plans to publish the associations later this year. However, an SAEC official said "it would be preliminary to develop a meaningful diagnostic chip off this data."

Novavax has begun a phase III trial of its SARS-CoV-2 vaccine, according to the New York Times.

Vox reports that the Trump Administration may limit student visas for individuals from some countries to two years.

The governor of New York says the state will conduct its own review of any SARS-CoV-2 vaccine, NPR reports.

This week in Science: Neanderthal Y chromosomes replaced by Homo sapiens Y chromosomes, and more.