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Jun 25, 2018

Breast, Lung Cancer Outcomes Informed by Gene Expression of Individual Infiltrating T Cells

Two new studies have uncovered expression-defined T cell subsets that seem to coincide with better or worse outcomes in breast cancer or non-small cell lung cancer.

Jun 14, 2018

Breast, Lung Cancer Genetics Highlight Mutations Linked to Drug Response, Prognosis

New tumor profiling papers stemming from prior clinical trials led to informative mutations in early-stage, ER+/HER2- breast cancer and lung squamous cell carcinoma.

Apr 03, 2018

TCGA Pan-Cancer Studies Describe New Tumor Features, Subtypes

With integrated data for thousands of TCGA tumors, teams explored cancer subtypes, searched for prognostic insights, began mapping immune cell interactions, and more.

Jan 29, 2018

Esophageal Cancer GWAS Leads to Low-Frequency Risk Variants

Exome sequences from thousands of Chinese individuals with or without esophageal squamous cell carcinoma led to six new germline risk variants.

Aug 08, 2017

Transcriptomics Reveals Tissue-Agnostic Features in Adenocarcinomas, Squamous Cell Carcinomas

A new analysis hints that adenocarcinomas or squamous cell carcinomas may have certain overlapping expression patterns, regardless of the tissue of origin.

May 09, 2016

Lung Cancer Subtypes Have Different Recurrent Mutations, Study Finds

Exome sequences and copy number patterns suggest lung adenocarcinoma and squamous cell carcinoma are each marked by specific somatic mutations and driver genes.

Sep 11, 2015

Launching Saliva Detection Test for Oral Cancer, PeriRx Sees Opportunity for Early-Stage Disease Dx

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The kit targets several mRNA biomarkers and is the first in a series of salivary diagnostic kits the firm plans to develop for early-stage disease diagnostics.

Jun 17, 2014

NCI, Foundation Medicine, and Five Pharma Firms Kick off Lung-MAP Trial

NEW YORK (GenomeWeb) — A group of pharmaceutical companies, research groups, foundations, and the clinical sequencing firm Foundation Medicine have joined to initiate a multi-drug, multi-arm, biomarker-driven clinical trial for patients with squamous cell carcinoma called the Lung Cancer Master P

May 30, 2013

Study Finds Lung Cancer Subtype Test from UNC, Startup GeneCentric to be Accurate, Reproducible

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A team led by clinical researchers from the University of North Carolina, Chapel Hill, has published a peer-reviewed study describing the development and validation of a gene expression-based predictor of lung cancer histology for formalin-fixed, paraffin-embedded tissue samples.

Sep 10, 2012

TCGA Team Reports on Squamous Cell Lung Cancer Findings

NEW YORK (GenomeWeb News) – In a study appearing online yesterday in Nature, members of The Cancer Genome Atlas reported on the progress they've made in characterizing a form of lung cancer called squamous cell carcinoma.

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The Scan

UK Bioethics Group Gives Cautious OK for Genetically Modifying Human Embryos

The UK's Nuffield Council on Bioethics says genetically modifying human embryos could be morally permissible, according to the Guardian.

CRISPR-Induced Damage?

A new Nature Biotechnology paper reports that CRISPR-Cas9 gene editing can lead to large deletions or complex rearrangements that could be pathogenic.

'Fax' It Over

The Wall Street Journal likens a prototype developed by Synthetic Genomics to a "biological fax machine."

This Week in PNAS

In PNAS this week: strategy for reactivating Rett syndrome-linked MECP2, small molecules able to suppress Staphylococcus aureus virulence, and more.

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