Using single-cell RNA sequencing and lineage tracing in a mouse model, researchers followed skin stem cell expression patterns in response to skin injury.
In Nature this week: Armillaria fungal genomes; risk variants linked to asthma, eczema, and hay fever; and more.
A genome-wide association meta-analysis involving hundreds of thousands of individuals led to 130 new and known risk variants linked to all three allergic conditions.
After identifying mutations in CARD11 in individuals with severe atopic dermatitis, investigators began untangling potential signaling consequences.
An autosomal dominant form of vibratory urticaria has been linked to a missense mutation in the ADGRE2 gene that appears to affect mast cell function and inflammation.
In Nature this week: DNA-free genome editing in plants, new risk loci for atopic dermatitis, and more.
Ten new atopic dermatitis risk loci turned up in a genome-wide association study meta-analysis involving hundreds of thousands of individuals.
Individuals who failed to clear a bacterial infection had variable skin microbiomes before exposure to the bug, but converged on similar skin microbiomes afterwards.
Nine members of the HMO Research Network "will use detailed clinical profiles to search for potential subjects to enroll into … serious adverse events research projects using their electronic medical record databases," iSAEC said in a statement.
Pharmacogenomics studies presented at the American Association for Cancer Research's annual meeting in Denver, Colo.
Publication of He Jiankui's work on gene-edited infants would raise ethical concerns for journals, Wired and others report.
The New York Times reports that evidence linking trauma in one generation to epigenetic effects that influence subsequent generations may be overstated.
ScienceInsider reports that US National Institutes of Health researchers were told in the fall they could not obtain new human fetal tissue.
In PNAS this week: skin pigmentation evolution among KhoeSan, biomarkers for dengue virus progression, and more.