sickle cell anemia | GenomeWeb

sickle cell anemia

Sickle Change

Stanford researchers use CRISPR to edit sickle cell mutations, possibly laying the groundwork for a clinical trial, Reuters reports.

This Week in Science

In Science this week: approach to uncover recent changes in allele frequencies, and more.

Utah's Dana Carroll, UC Berkeley's Jacob Corn, and their colleagues replaced the sickle cell disease mutation with the wild-type gene via HDR.

Researchers describe using a CRISPR approach to edit the sickle cell gene in vitro, the Los Angeles Times reports.

This Week in PNAS

In PNAS this week: work toward a CRISPR/Cas9-based approach to treat beta-thalassemia or sickle cell disease, bacteriophages uncovered in human stool, and more.

This Week in Nature

In Nature this week: Exome Aggregation Consortium analysis of some 60,000 exomes, and more.

Scientists introduced an indel to a promoter region to mimic a benign, naturally-occurring mutation that activated fetal hemoglobin production.

Another Tweak Here

Protective genetic mutations are providing a blueprint for companies wanting to treat sickle cell, Scientific American reports.

The partners will focus on developing gene editing-based treatments for cystic fibrosis and sickle cell disease, among other diseases.

By editing a promoter of an enhancer of the mutated hemoglobin responsible for sickle cell disease, the researchers may have found a way to treat it.

Pages

In Genome Biology this week: comparative genomics study of Aspergillus, genetic variation in indigenous African cattle, and more.

Some people who harbor genetic variants associated with disease show no signs and may give insight into the continuum of symptoms, Spectrum reports.

Some 57 snow monkeys at a Japanese zoo were found to be rhesus macaque hybrids, which are banned in Japan.

British researchers say they've been removed from EU grant applications, according to the Guardian.