Researchers from Hong Kong imputed transcriptomes from GWAS data and compared them to drug-induced gene expression profiles.
Even in schizophrenia cases lacking intellectual disability, investigators found that rare mutations in genes normally resistant to loss-of-function changes were enriched.
In Nature this week: fetal variants influence maternal risk of preeclampsia, and more.
Researchers identified truncating, psychosis-related mutations in RBM12 in a family affected by schizophrenia or other psychosis disorders.
In PNAS this week: archaeal evolutionary patterns; early life stress, HDAC1, and genetic susceptibility to schizophrenia; and more.
Researchers for the InPSYght project are sequencing 10,000 genomes and generating linked-read data for 500 to better understand schizophrenia and bipolar disorder.
Using genotyping and tissue-specific expression data from the Genotype-Tissue Expression project, researchers characterized Neanderthal allele-specific expression.
The international team of researchers also examined the genetic ties between personality traits and psychiatric disorders.
Using CNV profiles for more than 40,000 individuals with or without schizophrenia, researchers got a refined look at gains and losses linked to the condition.
In Genome Biology this week: single-cell transcriptomic study of embryonic stem cell differentiation, epigenome-wide association study of schizophrenia, and more.
While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.
Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.
In Nature this week: paternal age associated with de novo mutations in children, and more.
Nature News writes that researchers are still wrangling over the role of the p-value.