schizophrenia
Schizophrenia Risk Variants Functionally Validated With Massively Parallel Reporter Assay
Investigators used an MPRA to functionally validate more than 5,000 schizophrenia GWAS variants in primary human neural progenitor cells.
Study Finds Mechanism Linking Noncoding Risk Locus, Disease-Related Cellular Phenotypes
Using ATAC-seq and CRISPR-Cas9 editing in cell lines, researchers established a link between a noncoding schizophrenia risk locus and cellular phenotypes.
Schizophrenia Ties to Mosaic CNVs Suggest Early Developmental Origins of the Disease
Analyzing case-control genotyping profiles, researchers saw somatic copy number changes recurring in two genes in individuals with schizophrenia.
Schizophrenia Risk Genes Coexpressed Differently Across Lifetime, Brain Regions
RNA sequencing of 833 post-mortem brain samples revealed changes in coexpression patterns and novel gene associations involved in the development of schizophrenia.
Protein-Truncating Variants Confer Schizophrenia Risk Across Human Populations
A recent study also found two new genes involved in schizophrenia risk that could become potential therapeutic targets.