schizophrenia Schizophrenia Risk Variants Functionally Validated With Massively Parallel Reporter Assay Investigators used an MPRA to functionally validate more than 5,000 schizophrenia GWAS variants in primary human neural progenitor cells. Study Finds Mechanism Linking Noncoding Risk Locus, Disease-Related Cellular Phenotypes Using ATAC-seq and CRISPR-Cas9 editing in cell lines, researchers established a link between a noncoding schizophrenia risk locus and cellular phenotypes. Schizophrenia Ties to Mosaic CNVs Suggest Early Developmental Origins of the Disease Analyzing case-control genotyping profiles, researchers saw somatic copy number changes recurring in two genes in individuals with schizophrenia. Schizophrenia Risk Genes Coexpressed Differently Across Lifetime, Brain Regions RNA sequencing of 833 post-mortem brain samples revealed changes in coexpression patterns and novel gene associations involved in the development of schizophrenia. Protein-Truncating Variants Confer Schizophrenia Risk Across Human Populations A recent study also found two new genes involved in schizophrenia risk that could become potential therapeutic targets. Jan 17, 2023 Rare Single-Gene Variants Confer High Risk for Mental Health Conditions, Geisinger Study Shows Premium Dec 14, 2022 Study Links Maternal Mental Illness-Related Variants to Perinatal Risk Factors For Offspring Dec 5, 2022 Cross-Trait Meta-Analysis Explores Potential Pleiotropy Across Psychiatric Conditions Oct 13, 2022 Schizophrenia Neuron Single-Nucleus Sequencing Study Finds Impairment in Upper Cortex Layers Sep 27, 2022 Neuropsychiatric Disease Clues Drawn From Enhancer Expression Analysis Sep 14, 2022 Polygenic Risk Scores for Neuropsychiatric Conditions in Civilians Are Generalizable to Veterans Aug 17, 2022 Schizophrenia Study Implicates Ultrarare Variants in Cognitive Features Jun 23, 2022 NYGC Psychiatric Disease Database Project Aims to Kickstart Precision Medicine for Mental Illness Premium Apr 6, 2022 Schizophrenia, Bipolar Disorder Risk Traced to Common, Rare Variants in New Genetic Studies Jan 21, 2022 New Approach Identifies Candidate Causal Variants for Neuropsychiatric, Neurodevelopmental Conditions Oct 27, 2021 Polygenic Risk Scores Edge Toward Clinic, Though Disease Prediction Utility Questions Linger Premium Oct 22, 2021 SUPER Psychosis Study Presented at ASHG Digs Into Relationships of Rare Variants, Phenotypes Sep 7, 2021 Polygenic Risk Score Addition Does Not Improve Models Predicting Schizophrenia Prognosis Mar 26, 2021 Low-Coverage Sequencing Effectively IDs Novel Variants in Underrepresented Populations Mar 22, 2021 Ultra-Rare Genetic Variants in Protocadherin Gene Linked to Schizophrenia Mar 8, 2021 Case-Case GWAS Approach Identifies Loci That Differ in Frequency Across Psychiatric Disorders Feb 8, 2021 Spatial Transcriptomics Study Refines View Across Layers of Human Brain Region Jan 19, 2021 Psychiatric Disorder Risk Affected by Dysregulation of RNA-Binding Proteins May 14, 2020 Brain Proteins May Mediate Effects of Genetic Variants on Some Neurological Phenotypes Mar 16, 2020 Gene Expression Study of Brain Cell Layer Finds New Schizophrenia Risk Loci Load More Breaking News New Products Posted to GenomeWeb: Integra Biosciences, DNAstack, Bruker Angolan Namib Desert Population Analysis Uncovers New Ancestry Group With Deep Divergence Cedars-Sinai Sets Up $25M Single Cell Precision Medicine Center In Brief This Week: DermTech, Cerca Biotech, Colossal Biosciences, Biocept, Abbott, More Cue Health to Implement Shareholder Rights Plan The Scan Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.