schizophrenia
Polygenic Risk Scores Edge Toward Clinic, Though Disease Prediction Utility Questions Linger
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Researchers have conflicting interpretations of recent studies into how much polygenic risk scores might contribute to disease risk predictions.
SUPER Psychosis Study Presented at ASHG Digs Into Relationships of Rare Variants, Phenotypes
Using sequence data for tens of thousands of psychotic disease cases and controls, researchers have begun unearthing specific phenotypes linked to rare variants.
Polygenic Risk Score Addition Does Not Improve Models Predicting Schizophrenia Prognosis
The findings highlight the need for polygenic risk scores to not only be predictive but also provide additional information that cannot be captured elsewhere more easily.
Low-Coverage Sequencing Effectively IDs Novel Variants in Underrepresented Populations
The researchers found that sequencing at a depth of 4x or higher captured
Ultra-Rare Genetic Variants in Protocadherin Gene Linked to Schizophrenia
By focusing their genomic analysis on an Ashkenazi Jewish population, researchers uncovered ultra-rare variants associated with schizophrenia.