schizophrenia
Polygenic Risk Score Addition Does Not Improve Models Predicting Schizophrenia Prognosis
The findings highlight the need for polygenic risk scores to not only be predictive but also provide additional information that cannot be captured elsewhere more easily.
Low-Coverage Sequencing Effectively IDs Novel Variants in Underrepresented Populations
The researchers found that sequencing at a depth of 4x or higher captured
Ultra-Rare Genetic Variants in Protocadherin Gene Linked to Schizophrenia
By focusing their genomic analysis on an Ashkenazi Jewish population, researchers uncovered ultra-rare variants associated with schizophrenia.
Case-Case GWAS Approach Identifies Loci That Differ in Frequency Across Psychiatric Disorders
The approach provides new insights into genetic differences between various disorders in order to improve their diagnosis and treatment.
PNAS Papers on Neurodevelopment Risk Scores in Placenta, Ancient Human Dispersal to China, More
In PNAS this week: placental expression risk scores for schizophrenia, ancient DNA-based analysis of human arrival in China, and more.