Even in schizophrenia cases lacking intellectual disability, investigators found that rare mutations in genes normally resistant to loss-of-function changes were enriched.
In Nature this week: fetal variants influence maternal risk of preeclampsia, and more.
Researchers identified truncating, psychosis-related mutations in RBM12 in a family affected by schizophrenia or other psychosis disorders.
In PNAS this week: archaeal evolutionary patterns; early life stress, HDAC1, and genetic susceptibility to schizophrenia; and more.
Researchers for the InPSYght project are sequencing 10,000 genomes and generating linked-read data for 500 to better understand schizophrenia and bipolar disorder.
Using genotyping and tissue-specific expression data from the Genotype-Tissue Expression project, researchers characterized Neanderthal allele-specific expression.
The international team of researchers also examined the genetic ties between personality traits and psychiatric disorders.
Using CNV profiles for more than 40,000 individuals with or without schizophrenia, researchers got a refined look at gains and losses linked to the condition.
In Genome Biology this week: single-cell transcriptomic study of embryonic stem cell differentiation, epigenome-wide association study of schizophrenia, and more.
Blood tests looking for biomarker changes could catch mental illnesses earlier, Newsweek reports.
Helix customers can purchase apps that interpret different aspects of their genome, Technology Review reports.
The New York Times reports that a number of companies and research institutes are pursuing gene therapies.
Salmon with shorter telomeres survive to make the trip back to their river homes, New Scientist reports.
In PLOS this week: vaginal microbiome composition, population patterns of Chagas-carrying Rhodnius ecuadoriensis, and more.