Using a deep learning approach to study mutations in target sites of RNA-binding proteins, researchers identified DDHD2 as a candidate schizophrenia risk gene.
The study also found that certain genes may influence multiple complex traits, while others only affect one phenotype, making them worthwhile therapeutic targets.
In Nature this week: missense variant linked to decreased height among Peruvians, genetic basis of sex-biased vulnerability to certain disorders, and more.
Investigators tracked down a methylation signature in blood that corresponded with features found in postmortem brain samples from schizophrenia cases.
In Science this week: genetic mutation linked to schizophrenia among South African Xhosas, engineering the bee microbiome to address parasite and virus, and more.
While de novo mutations appeared to make relatively modest contributions to schizophrenia risk, they recurrently affected evolutionarily conserved genes.
Imperial College London researchers are shifting away from testing a COVID-19 vaccine to focus on combating newly emerging SARS-CoV-2 variants, the Independent says.
