schizophrenia

Researchers prioritized schizophrenia risk SNPs from genome-wide association studies and used functional genomics to find transcription factor-disrupting risk SNPs.

This Week in Science

In Science this week: discussion of combining immunotherapies with targeted treatments, and more.

Two independent teams described potential roles for gut microbes, and the compounds they produce, in schizophrenia, depression, and mental quality of life.

Polygenic risk scores for depression, bipolar disorder, and schizophrenia are associated with depression in a general population cohort.

Using UK Biobank and 23andMe data, researchers found 352 loci influencing sleep time preferences, including sites near brain- and retina-expressed genes.

This Week in Science

In Science this week: the PsychENCODE Consortium reports on the molecular mechanisms of neuropsychiatric disorders, and more.

In a set of new studies, members of an international team mapped gene variation, expression, and regulatory interactions in developing and adult human brains.

Given that genetic susceptibility to schizophrenia is highly polygenic, the researchers found that the risk scores had some utility as prognostic biomarkers.

Screening of disease-linked cell types might bolster drug discovery efforts in schizophrenia, according to a proof-of-concept study.

An analysis on thousands of Japanese individuals with autism spectrum disorder or schizophrenia uncovered shared pathways and an abundance of rare exonic copy number variants.

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NPR reports that researchers in Italy are testing a gene drive aimed at controlling mosquito populations.

Researchers may experience the effects of the government shutdown for a while, the Los Angeles Times reports.

A new study finds that the majority of patients at a Tijuana clinic received a diagnosis after first-line genome sequencing, the San Diego Union-Tribune reports.

In Genome Biology this week: post-transcriptional modification-based stratification of glioblastoma, single-cell analysis of gene expression and methylation in human iPSCs, and more.