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schizophrenia

Schizophrenia Risk Variants Functionally Validated With Massively Parallel Reporter Assay

Investigators used an MPRA to functionally validate more than 5,000 schizophrenia GWAS variants in primary human neural progenitor cells.

Study Finds Mechanism Linking Noncoding Risk Locus, Disease-Related Cellular Phenotypes

Using ATAC-seq and CRISPR-Cas9 editing in cell lines, researchers established a link between a noncoding schizophrenia risk locus and cellular phenotypes.

Schizophrenia Ties to Mosaic CNVs Suggest Early Developmental Origins of the Disease

Analyzing case-control genotyping profiles, researchers saw somatic copy number changes recurring in two genes in individuals with schizophrenia.

Schizophrenia Risk Genes Coexpressed Differently Across Lifetime, Brain Regions

RNA sequencing of 833 post-mortem brain samples revealed changes in coexpression patterns and novel gene associations involved in the development of schizophrenia.

Protein-Truncating Variants Confer Schizophrenia Risk Across Human Populations

A recent study also found two new genes involved in schizophrenia risk that could become potential therapeutic targets.

Jan 17, 2023

Rare Single-Gene Variants Confer High Risk for Mental Health Conditions, Geisinger Study Shows
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Dec 14, 2022

Study Links Maternal Mental Illness-Related Variants to Perinatal Risk Factors For Offspring

Dec 5, 2022

Cross-Trait Meta-Analysis Explores Potential Pleiotropy Across Psychiatric Conditions

Oct 13, 2022

Schizophrenia Neuron Single-Nucleus Sequencing Study Finds Impairment in Upper Cortex Layers

Sep 27, 2022

Neuropsychiatric Disease Clues Drawn From Enhancer Expression Analysis

Sep 14, 2022

Polygenic Risk Scores for Neuropsychiatric Conditions in Civilians Are Generalizable to Veterans

Aug 17, 2022

Schizophrenia Study Implicates Ultrarare Variants in Cognitive Features

Jun 23, 2022

NYGC Psychiatric Disease Database Project Aims to Kickstart Precision Medicine for Mental Illness
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Apr 6, 2022

Schizophrenia, Bipolar Disorder Risk Traced to Common, Rare Variants in New Genetic Studies

Jan 21, 2022

New Approach Identifies Candidate Causal Variants for Neuropsychiatric, Neurodevelopmental Conditions

Oct 27, 2021

Polygenic Risk Scores Edge Toward Clinic, Though Disease Prediction Utility Questions Linger
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Oct 22, 2021

SUPER Psychosis Study Presented at ASHG Digs Into Relationships of Rare Variants, Phenotypes

Sep 7, 2021

Polygenic Risk Score Addition Does Not Improve Models Predicting Schizophrenia Prognosis

Mar 26, 2021

Low-Coverage Sequencing Effectively IDs Novel Variants in Underrepresented Populations

Mar 22, 2021

Ultra-Rare Genetic Variants in Protocadherin Gene Linked to Schizophrenia

Mar 8, 2021

Case-Case GWAS Approach Identifies Loci That Differ in Frequency Across Psychiatric Disorders

Feb 8, 2021

Spatial Transcriptomics Study Refines View Across Layers of Human Brain Region

Jan 19, 2021

Psychiatric Disorder Risk Affected by Dysregulation of RNA-Binding Proteins

May 14, 2020

Brain Proteins May Mediate Effects of Genetic Variants on Some Neurological Phenotypes

Mar 16, 2020

Gene Expression Study of Brain Cell Layer Finds New Schizophrenia Risk Loci

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The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.