schizophrenia Polygenic Risk Score Addition Does Not Improve Models Predicting Schizophrenia Prognosis The findings highlight the need for polygenic risk scores to not only be predictive but also provide additional information that cannot be captured elsewhere more easily. Low-Coverage Sequencing Effectively IDs Novel Variants in Underrepresented Populations The researchers found that sequencing at a depth of 4x or higher captured Ultra-Rare Genetic Variants in Protocadherin Gene Linked to Schizophrenia By focusing their genomic analysis on an Ashkenazi Jewish population, researchers uncovered ultra-rare variants associated with schizophrenia. Case-Case GWAS Approach Identifies Loci That Differ in Frequency Across Psychiatric Disorders The approach provides new insights into genetic differences between various disorders in order to improve their diagnosis and treatment. PNAS Papers on Neurodevelopment Risk Scores in Placenta, Ancient Human Dispersal to China, More In PNAS this week: placental expression risk scores for schizophrenia, ancient DNA-based analysis of human arrival in China, and more. Jan 19, 2021 Psychiatric Disorder Risk Affected by Dysregulation of RNA-Binding Proteins May 14, 2020 Brain Proteins May Mediate Effects of Genetic Variants on Some Neurological Phenotypes Mar 16, 2020 Gene Expression Study of Brain Cell Layer Finds New Schizophrenia Risk Loci Feb 12, 2020 Schizophrenia Associated With Blood DNA Methylation Signature Jan 30, 2020 Schizophrenia Exome Sequencing Study in South African Population Reveals Rare Mutations, Pathways Jan 14, 2020 Schizophrenia Exome Studies Delineate Role of De Novo Mutations Jan 8, 2020 Psychiatric Disorders, Body Mass Index Share Genetic Loci, Study Finds Jan 7, 2020 Anxiety GWAS On Million Veteran Program Data Uncovers New Loci Dec 12, 2019 Psychiatric Disorders Fall Into Groups With Shared Genetic Contributors in GWAS Meta-Analysis Nov 18, 2019 Schizophrenia Loci Overlap in East Asians, Europeans but Polygenic Risk Scores Don't Transfer Well Oct 16, 2019 Large-Scale Schizophrenia Exome Sequencing Study Identifies New Risk Genes Sep 25, 2019 Genetic Links Between Psychotic Experiences, Neuropsychiatric Diseases Uncovered in Study Aug 9, 2019 Circadian Expression of Genes Disrupted in Brains of Individuals With Schizophrenia May 3, 2019 Differential Methylation of Enhancer May Lead to Abnormal Dopamine Levels in Major Psychosis Apr 16, 2019 Ancient European, Pathogen DNA Data Promises to Shed Light on Brain Disorders, Infectious Disease Premium Mar 28, 2019 Schizophrenia Genes Prioritized in Zebrafish Mutant Study Mar 25, 2019 Schizophrenia Genes, Pathways in Brain Identified With Transcriptome Imputation Approach Feb 25, 2019 Autism Spectrum Disorder GWAS Highlights Common Risk Variants, Overlap With Other Conditions Feb 8, 2019 Schizophrenia Regulatory Mechanisms Revealed by Risk SNP Functional Analysis Feb 6, 2019 Schizophrenia, Depression Studies Suggest Gut Microbiome May Influence Mental Health Load More Breaking News In Brief This Week: Illumina, Personalis, Proteomedix, and More Ancient DNA Details Population Dynamics Within Andean Tiwanaku Civilization Genomic Data Spanning 2K Years Gives Glimpse of Etruscan Origins, Population Changes People in the News: New Appointments at Hologic, Akoya Biosciences, Caris Life Sciences, More At NSGC, Genetic Counselors Address Race-Based Medicine, Ways to Change New Products Posted to GenomeWeb: Becton Dickinson, Cosmos-ID, OncoDNA, More The Scan US Booster Eligibility Decision The US CDC director recommends that people at high risk of developing COVID-19 due to their jobs also be eligible for COVID-19 boosters, in addition to those 65 years old and older or with underlying medical conditions. Arizona Bill Before Judge The Arizona Daily Star reports that a judge weighing whether a new Arizona law restricting abortion due to genetic conditions is a ban or a restriction. Additional Genes Wales is rolling out new genetic testing service for cancer patients, according to BBC News. Science Papers Examine State of Human Genomic Research, Single-Cell Protein Quantification In Science this week: a number of editorials and policy reports discuss advances in human genomic research, and more.