schizophrenia Low-Coverage Sequencing Effectively IDs Novel Variants in Underrepresented Populations The researchers found that sequencing at a depth of 4x or higher captured Ultra-Rare Genetic Variants in Protocadherin Gene Linked to Schizophrenia By focusing their genomic analysis on an Ashkenazi Jewish population, researchers uncovered ultra-rare variants associated with schizophrenia. Case-Case GWAS Approach Identifies Loci That Differ in Frequency Across Psychiatric Disorders The approach provides new insights into genetic differences between various disorders in order to improve their diagnosis and treatment. Spatial Transcriptomics Study Refines View Across Layers of Human Brain Region Spatial expression features in six layers of the human dorsolateral prefrontal cortex provided a look at laminar markers and discovered ties to neuropsychiatric disease genes. Psychiatric Disorder Risk Affected by Dysregulation of RNA-Binding Proteins Using a deep learning approach to study mutations in target sites of RNA-binding proteins, researchers identified DDHD2 as a candidate schizophrenia risk gene. May 14, 2020 Brain Proteins May Mediate Effects of Genetic Variants on Some Neurological Phenotypes Mar 16, 2020 Gene Expression Study of Brain Cell Layer Finds New Schizophrenia Risk Loci Feb 12, 2020 Schizophrenia Associated With Blood DNA Methylation Signature Jan 30, 2020 Schizophrenia Exome Sequencing Study in South African Population Reveals Rare Mutations, Pathways Jan 14, 2020 Schizophrenia Exome Studies Delineate Role of De Novo Mutations Jan 8, 2020 Psychiatric Disorders, Body Mass Index Share Genetic Loci, Study Finds Jan 7, 2020 Anxiety GWAS On Million Veteran Program Data Uncovers New Loci Dec 12, 2019 Psychiatric Disorders Fall Into Groups With Shared Genetic Contributors in GWAS Meta-Analysis Nov 18, 2019 Schizophrenia Loci Overlap in East Asians, Europeans but Polygenic Risk Scores Don't Transfer Well Oct 16, 2019 Large-Scale Schizophrenia Exome Sequencing Study Identifies New Risk Genes Sep 25, 2019 Genetic Links Between Psychotic Experiences, Neuropsychiatric Diseases Uncovered in Study Aug 9, 2019 Circadian Expression of Genes Disrupted in Brains of Individuals With Schizophrenia May 3, 2019 Differential Methylation of Enhancer May Lead to Abnormal Dopamine Levels in Major Psychosis Apr 16, 2019 Ancient European, Pathogen DNA Data Promises to Shed Light on Brain Disorders, Infectious Disease Premium Mar 28, 2019 Schizophrenia Genes Prioritized in Zebrafish Mutant Study Mar 25, 2019 Schizophrenia Genes, Pathways in Brain Identified With Transcriptome Imputation Approach Feb 25, 2019 Autism Spectrum Disorder GWAS Highlights Common Risk Variants, Overlap With Other Conditions Feb 8, 2019 Schizophrenia Regulatory Mechanisms Revealed by Risk SNP Functional Analysis Feb 6, 2019 Schizophrenia, Depression Studies Suggest Gut Microbiome May Influence Mental Health Jan 30, 2019 Polygenic Risk Scores for Three Psychiatric Disorders Linked to Depression Diagnoses Load More Breaking News Alzheimer's Disease Phosphoproteomics Study Uncovers Signaling Abnormalities Genetic Analysis of H. Pylori Indicates Americas Colonized in One Main Migration Event BillionToOne Raises $55M in Series B Financing GeninCode to Launch Cardiovascular Disease Risk Tests in US With Eversana Top Five Articles on GenomeWeb Last Week: Illumina, Liquid Biopsy, Thermo Fisher Scientific, and More Becton Dickinson Sues Beckman Coulter Over Cell Analysis, Sorting IP The Scan Another Resignation According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug. Novavax Finds Its Vaccine Effective Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19. Can't Be Used The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports. PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.