The researchers conducted a genome-wide association study and other analyses using about 47,000 research participants from 23andMe.

Through a genome-wide association study, meta-analysis, and systems analysis, researchers saw enhanced common variant distribution in mutation-intolerant genes.

Using pathway and network analyses, researchers identified overlapping genes and biological processes behind smoking and schizophrenia, including new candidate genes.

This Week in Science

In Science this week: genetic overlap between five psychiatric disorders, and more.

Using post-mortem data, researchers explored similarities and differences between autism, schizophrenia, bipolar disorder, alcoholism, and depression.

A genome-wide association study meta-analysis found bipolar disorder patients with poor response to lithium have more polygenic risk factors for schizophrenia.

The researchers searched for schizophrenia risk loci using cohorts of both Chinese and European ancestry.

Researchers from Hong Kong imputed transcriptomes from GWAS data and compared them to drug-induced gene expression profiles.

Even in schizophrenia cases lacking intellectual disability, investigators found that rare mutations in genes normally resistant to loss-of-function changes were enriched.

This Week in Nature

In Nature this week: fetal variants influence maternal risk of preeclampsia, and more.


Berkeley researchers have engineered yeast to make the molecule behind the hoppy taste of beer, Quartz reports.

King's College London researchers examine the influence of school type and genetics on academic achievement.

FiveThirtyEight writes that most who take a direct-to-consumer BRCA1/2 genetic test won't learn much from it.

In Science this week: early life experience influence somatic variation in the genome, and more.