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Tool Detects Pediatric Bone Tumors From Liquid Biopsies Based on Epigenetic Profiles

Epigenetic signatures of Ewing sarcoma affect cell-free DNA fragmentation patterns and can be used to detect cancer.

Nonprofit Count Me In to Return Genomic Results to Patients With Rare Cancers
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With a new $16 million NCI grant, Count Me In is working with the Broad and Dana-Farber to engage osteosarcoma and leiomyosarcoma patients in their own care and in research.

Secondary Tumor Risk in Pediatric Cancer Survivors Linked to Germline Variants, Treatment Type

An analysis of pediatric cancer survivors suggests subsequent neoplasm risk can increase after certain genotoxic treatments in those with DNA repair gene changes.

Human Tumor Atlas Network Team Shares Strategy for Tracking Tumor Transitions

A new paper outlines an upcoming effort to trace tumor development and trajectory in time and space using single-cell genetics and other genomic methods.

B Cell Gene Expression Profiling May Enable Cancer Immunotherapy CDx Test
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Researchers have identified immune cell gene expression signatures that could one day be developed into tests to predict response to treatment.

Jan 15, 2020

Presence of B Cells in Tumors Associated With Favorable Immunotherapy Outcomes

Mar 31, 2019

CAR T Cell Therapies Targeting HER2, Mesothelin Show Activity in Solid Tumors
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Oct 18, 2018

Broad Institute Launches Patient-Partnered Cancer Research Non-Profit Organization

Aug 30, 2018

Subset of Ewing Sarcomas Arise from Early, Complex Genome Rearrangements

Aug 23, 2018

Multi-Omic Analysis of Rhabdomyosarcoma Points to Drug Targets in Deregulated Pathways

Aug 23, 2018

Researchers Validate ArcherDx Targeted Sequencing Approach for Sarcoma Gene Fusions
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Jun 18, 2018

Recurrent Rearrangements Identified in Rare Infant Soft Tissue Tumors

Jun 4, 2018

MSI Tumor Analysis Implicates Lynch Syndrome in Several New Cancer Types

Apr 19, 2018

AACR Symposium Features Genomic, Proteomic Searches for Immunotherapy Improvements

Mar 20, 2018

Cofactor Genomics, NCI Partner to Validate RNA-Based Immune Profiling Assay

Feb 16, 2018

Cofactor Pushes RNA-Based Dx Goals With New Immuno-Oncology Assay
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Nov 17, 2017

NanoString-Based Pan-Sarcoma Fusion Gene Assay Shows Promise as First-Line Dx
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Jun 3, 2017

French Genome Profiling Trial Points to Frequent Actionable Mutations in Advanced Cancer

May 8, 2017

Oxford Gene Technology Bets on Design, Flexibility to Woo Clinical Labs With New NGS Cancer Panel
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Jan 31, 2017

Ewing Sarcomas Contain Spectrum of DNA Methylation Changes

Jan 30, 2017

Columbia U, Life Raft Use Pathway Approach to Find New Therapies for Resistant GI Tumors
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Aug 5, 2016

Sarcoma Patient Targeted Sequencing IDs Germline Mutations in Known Cancer Genes

Jun 22, 2016

NIH Panel Approves CRISPR-Edited T Cell Safety Trial, First In-Human Use
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Nov 2, 2015

Team Finds Recurrent Fusion in Aggressive Angiosarcomas

Oct 15, 2015

Findings Support Prognostic Potential for Gene Signature in Some Forms of Rhabdomyosarcoma

Breaking News
The Scan

Push Toward Approval

The Wall Street Journal reports the US Food and Drug Administration is under pressure to grant full approval to SARS-CoV-2 vaccines.

Deer Exposure

About 40 percent of deer in a handful of US states carry antibodies to SARS-CoV-2, according to Nature News.

Millions But Not Enough

NPR reports the US is set to send 110 million SARS-CoV-2 vaccine doses abroad, but that billions are needed.

PNAS Papers on CRISPR-Edited Cancer Models, Multiple Sclerosis Neuroinflammation, Parasitic Wasps

In PNAS this week: gene-editing approach for developing cancer models, role of extracellular proteins in multiple sclerosis, and more.