retinoblastoma
Children's Hospital LA Researcher Wins $2.8M NIH Grant for Retinoblastoma Liquid Biopsy Study
The international study will sample the aqueous humor found in children's eyes and follow participants for at least two years to monitor for cancer recurrence.
Researchers showed that methylation patterns on cell-free DNA in the eye can differentiate retinoblastomas into more or less aggressive subtypes.
Retinoblastoma Study Reveals Pathogenesis Gene Downstream of Mutated RB1
With a series of omics analyses and experiments, researchers linked the estrogen-related receptor gamma gene ESRRG to retinoblastoma pathogenesis and hypoxia adaptations.
Using tumor and matched normal sequence data generated for tens of thousands of cancer patients, the team identified mosaic cancer susceptibility in around one in 1,000 cases.
Researchers have been able to detect and characterize genomic alterations in DNA floating in the aqueous humor of the eye, opening the door to new prognostic studies.