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Plasmodium

Gene Screen Leads to Potential Malaria Targets in Liver-Stage Plasmodium Parasites

Sequencing and other experiments on barcoded Plasmodium berghei mutant strains helped researchers narrow in on key metabolic pathways in the parasite's liver stage.

Malaria Drug Resistance Genetic Features Profiled in Southeast Asia

Researchers used genomic and transcriptomic data of isolates from seven Southeast Asian countries to find resistance-relevant pathways and expression quantitative trait loci.

Researchers Explore Population Patterns in Zoonotic Malaria Parasite

Three genetically distinct sub-populations appeared when the team sequenced and compared 48 clinical isolates of Plasmodium knowlesi and five lab lines.

Malaria GWAS Uncovers Protective Locus

A chromosome 4 locus near glycophorin-coding genes appears to decrease the risk of severe malaria in African children, particularly those from East Africa.

U of Maryland-led Statistical Study Points to Co-evolution of Plasmodium Parasite, Mammalian Hosts
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The results showed that mammalian-infecting Plasmodium evolved contemporaneously with their hosts, with little evidence of parasite host-switching on an evolutionary scale.

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The Scan

Machine Learning Helps ID Molecular Mechanisms of Pancreatic Islet Beta Cell Subtypes in Type 2 Diabetes

The approach helps overcome limitations of previous studies that had investigated the molecular mechanisms of pancreatic islet beta cells, the authors write in their Nature Genetics paper.

Culture-Based Methods, Shotgun Sequencing Reveal Transmission of Bifidobacterium Strains From Mothers to Infants

In a Nature Communications study, culture-based approaches along with shotgun sequencing give a better picture of the microbial strains transmitted from mothers to infants.

Microbial Communities Can Help Trees Adapt to Changing Climates

Tree seedlings that were inoculated with microbes from dry, warm, or cold sites could better survive drought, heat, and cold stress, according to a study in Science.

A Combination of Genetics and Environment Causes Cleft Lip

In a study published in Nature Communications, researchers investigate what combination of genetic and environmental factors come into play to cause cleft lip/palate.