Pediatric Cancer
Mutational Signatures Profiled in Pediatric Cancers
Researchers uncovered and analyzed mutational signatures in 27 cancer types or subtypes by analyzing genome sequences for nearly 800 tumors.
Pharmacotyping Links Childhood Leukemia Subtypes to Treatment Response
With drug sensitivity and genomic profiles on acute lymphoblastic leukemia cells, coupled with patient data, researchers saw pharmacotypes related to treatment response and outcomes.
Researchers showed that methylation patterns on cell-free DNA in the eye can differentiate retinoblastomas into more or less aggressive subtypes.
St. Jude, Broad Institute, Dana-Farber Partner to Advance Pediatric Cancer Research
The institutions have invested $60 million into the Pediatric Cancer Dependencies Accelerator to study cancer vulnerabilities and develop treatments.
Peripheral Neuroblastic Tumor Transcriptomes Point to Transitional Cell State
Single-cell RNA sequencing data from malignant and nonmalignant cells revealed prognostically important signatures linked to more aggressive tumor forms.