Pediatric Cancer News and reporting on pediatric cancer. Mutational Signatures Profiled in Pediatric Cancers Researchers uncovered and analyzed mutational signatures in 27 cancer types or subtypes by analyzing genome sequences for nearly 800 tumors. Pharmacotyping Links Childhood Leukemia Subtypes to Treatment Response With drug sensitivity and genomic profiles on acute lymphoblastic leukemia cells, coupled with patient data, researchers saw pharmacotypes related to treatment response and outcomes. Epigenetic Signatures in Eye Predict Rare Tumor Aggressiveness, Treatment Response Premium Researchers showed that methylation patterns on cell-free DNA in the eye can differentiate retinoblastomas into more or less aggressive subtypes. St. Jude, Broad Institute, Dana-Farber Partner to Advance Pediatric Cancer Research The institutions have invested $60 million into the Pediatric Cancer Dependencies Accelerator to study cancer vulnerabilities and develop treatments. Peripheral Neuroblastic Tumor Transcriptomes Point to Transitional Cell State Single-cell RNA sequencing data from malignant and nonmalignant cells revealed prognostically important signatures linked to more aggressive tumor forms. Sep 21, 2022 Medulloblastoma Molecular Studies Point to Cell Origins, Progenitor Differentiation Jul 25, 2022 Genetic Risk Score Helps Predict Severe Obesity Later in Life in Childhood Cancer Survivors Jul 12, 2022 NCCN Publishes First Guidelines for Pediatric Brain Cancer, Recommends Broad NGS Profiling Jul 6, 2022 Structural Variant Study Points to Pediatric Glioma Drivers, Prognostic Features May 20, 2022 MSK Starts Offering Pediatric Cancer Patients Whole-Genome, Transcriptome Sequencing Premium Apr 29, 2022 St. Jude Program Installing Nanopore Sequencing in Low-Income Countries to Diagnose Pediatric Blood Cancers Premium Apr 20, 2022 Proof-of-Principle Study Points to Possibility of Monitoring Pediatric ALL With Plasma Samples Apr 12, 2022 New Epigenomic Biomarker Could Predict CAR T-Cell Therapy Resistance in Advanced Childhood Leukemia Premium Mar 25, 2022 Initial KidsCanSeq Findings Reveal Medical Recommendations Stemming From Germline Tests Mar 21, 2022 NIH Launches New Childhood Cancer Genomics Program Mar 16, 2022 Pediatric Cancer Sequencing Expands Relapse Treatment Options in New Study Nov 12, 2021 Childhood Brain Tumors in Crosshairs of New CHOP-led Sequencing Biobank Effort Premium Oct 21, 2021 Germline Cancer Risk Genes May Hold Rhabdomyosarcoma Survival Clues, Study Suggests Oct 18, 2021 Analysis Finds Sibling Cascade Testing Could Be Cost Effective in Pediatric Cancer Jun 10, 2021 Molecular Profiling in Pediatric Cancer Trials Continues to Prove Valuable for Treatment Matching Premium Mar 1, 2021 TGen-Led Team Spots Pediatric, Pancreatic Cancer From cfDNA Fragments in Urine Premium Feb 16, 2021 MSK Team Explores Clinical Utility of Germline Testing for Pediatric Cancer Patients Dec 8, 2020 Genetic Loci Influence Risk of Cardiomyopathy in Pediatric Cancer Survivors of African Ancestry Dec 7, 2020 Neuroblastoma Super Enhancer Profiles Pinpoint Four Epigenetic Subtypes Nov 25, 2020 Pediatric Brain Tumor Proteomics Highlight Possible Treatment Targets, Biomarkers Load More Breaking News Cancer Prognoses Informed by Module-Based Approach, Study Finds People in the News at Illumina, Centogene, BioSkryb New Products Posted to GenomeWeb: Bio-Rad, BD, Analytik Jena, BioMérieux Genetic Technologies to Raise A$5M in Direct Stock Offering In Brief This Week: SD Biosensors, Meridian, Oncocyte, Opko Health, GeneDx, More The Scan Study Reveals New Details About Genetics of Major Cause of Female Infertility Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency. Circulating Tumor DNA Shows Potential as Biomarker in Rare Childhood Cancer A study in the Journal of Clinical Oncology has found that circulating tumor DNA levels in rhabdomyosarcoma may serve as a biomarker for prognosis. Study Recommends Cancer Screening for Dogs Beginning Age Seven, Depending on Breed PetDx researchers report in PLOS One that annual cancer screening for dogs should begin by age seven. White-Tailed Deer Harbor SARS-CoV-2 Variants No Longer Infecting Humans, Study Finds A new study in PNAS has found that white-tailed deer could act as a reservoir of SARS-CoV-2 variants no longer found among humans.