osteoarthritis Type 2 Diabetes, Osteoarthritis Comorbidity Traced to Obesity-Related Processes Researchers turned to genotyping, multiomics, and functional studies to untangle the processes contributing to type 2 diabetes and hip/knee osteoarthritis. Serum Protein Biomarkers Can Predict Worsening Knee Osteoarthritis The researchers said that being able to predict who is at risk of knee osteoarthritis progression will aid in the development of new treatments. Osteoarthritis-Associated Variants in Retinoic Acid Synthesis Gene Point to Potential Treatment A new study found that a drug that blocks retinoic acid metabolism could suppress mechano-inflammation in animal models of osteoarthritis. New Osteoarthritis Genetic Risk Loci Uncovered in Multi-Ancestry Analyses Researchers tracked down osteoarthritis-associated loci, along with related biological pathways, using data for nearly 484,400 Million Veteran Program and UK Biobank participants. Osteoarthritis GWAS Leads to Key Genes, Treatment Targets With a genome-wide association study and functional follow-up analyses, investigators saw 100 osteoarthritis-related loci including variants in potentially targetable genes and pathways. Jan 21, 2019 Genome-Wide Analysis More Than Doubles Loci Linked to Osteoarthritis Risk Oct 29, 2018 Osteoarthritis Risk Linked to Novel Genetic Loci Mar 19, 2018 Osteoarthritis Risk Linked to Nine Novel Loci by Sanger Institute-Led Team Mar 20, 2017 Icelandic DNA Sequences Lead to Rare Osteoarthritis Risk Variants Jul 15, 2015 Interleukin, NYU to Commercialize IL-1 Genetic Test for Osteoarthritis Progression Jan 24, 2013 NIAMS to Fund Research Cores for Musculoskeletal Conditions Sep 7, 2012 Miami's Hussman Institute Lands $2.5M for Persistent Pain Biomarker Hunt Jul 11, 2012 NIAMS to Fund Studies of Genes, Variants that Influence Disease Risk Aug 26, 2011 International Group Uses 1000 Genomes-Based Imputation to ID Osteoarthritis Risk Locus Feb 10, 2010 Novartis Eyeing US Market for Prexige Launch with Companion Test Premium Feb 4, 2010 Novartis Adds Companion Dx to Lumiracoxib Resubmission in Europe Oct 27, 2009 Eli Lilly Will Use GeneNews' Osteoarthritis Biomarker Technology Feb 4, 2009 Navigenics Launches Cheaper Annual Genomic Service; Will Doctors Bite? Premium Breaking News Compact Gene Editing Enzyme May Improve Success Rates of Gene Therapies People in the News at Veracyte, Invitae, Mount Sinai, InterVenn Biosciences, Applied BioCode, More New Products Posted to GenomeWeb: Qiagen, IDT, Revvity, Mission Bio, NRichDx, More FDA Releases Proposed Rule for Oversight of Laboratory-Developed Tests CStone Pharmaceuticals, Genetron Companion Diagnostic Receives NMPA Approval The Scan Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.