Using epigenetic data, expression profiles, gene editing, and more, researchers uncovered interactions in fat precursor cells that may explain FTO's role in obesity.
Researchers detected a truncating mutation in the carboxypeptidase E gene in members of a Sudanese family affected by extreme obesity, glucose metabolism problems, and other symptoms.
The researchers published a proof of principle in Nature Communications of a panel designed to look at epigenetic variation in adipose tissue and are using it to study obesity and metabolic syndromes.
Through unbiased and targeted metabolite testing on urine samples from thousands of individuals in the US and the UK, researchers have narrowed in on urine compounds that coincide with body mass index.
Through their meta-analyses, consortium researchers found roles for a number of pathways in obesity risk and highlighted the varied effects of loci on men and women.
In an editorial, officials from scientific societies in the US and China call for the international community to develop criteria and standards for human germline editing.
The US National Institutes of Health is to review studies that have received private support for conflicts of interest, according to the New York Times.
