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Some of these shared loci were associated with higher BMI, but some were linked to lower BMI, particularly those also linked to schizophrenia.

In a large group of participants followed for decades, baseline body mass index outperformed a SNP-based obesity risk score for predicting midlife weight.

Just Another Diet

Washington Post columnist writes that she is skeptical about DNA-based diets.

In Science this week: sequencing study of 523 ancient individuals from South and Central Asia, and more.

Different biological processes appear to drive body mass index during infancy and later in childhood and adulthood, which could inform obesity prevention strategies.

A gene-environment study involving more than 18,000 individuals suggests jogging and other forms of exercise may modify the genetic risk for obesity.

Rhythm has a drug called setmelanotide in Phase III development for genetic obesity disorders associated with variants within the melanocortin-4 pathway.

The researchers found that while BMI broadly increased over time in their Norwegian cohort, genetically predisposed individuals were more highly affected.

The firm, Phenomix Sciences, anticipates that its test will help drive adoption of medications for obesity at a time when patients are reluctant to take them.

But Useful?

Researchers question the value of a predictive genetic test for obesity, NPR reports.

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Reuters reports that Germany is seeking to sequence 5 percent of patient samples that test positive for SARS-CoV-2.

23andMe and Medscape say primary care physicians are increasingly more comfortable with discussing direct-to-consumer genetic testing results.

The publisher of the Science family of journals will allow some authors to place peer-reviewed versions of their papers into publicly accessible repositories.

In Science this week: analysis of genome-wide association studies of chronic kidney disease, and more.