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In Science this week: 29 widespread antiviral gene cassettes uncovered, and more.

A Regeneron-led team identified four variants that affect LDL cholesterol levels and are much more prevalent among Southwestern American Indians.

Researchers found that diurnal gut microbe fluctuations are disrupted in individuals with type 2 diabetes, leading to a bacterial signature for risk profiling.

In PLOS this week: genome-wide association study of agronomic traits in sugarcane, breastfeeding can modulate body-mass index among individuals at genetic risk of obesity, and more.

Northern and southern Italians further developed what appear to be genetic adaptations affecting susceptibility to obesity and melanoma, respectively.

In animal models, loss of ALK was associated with protection from obesity, even when the animals were on a high-fat diet.

Researchers saw a shift toward lower gut bifidobacterial levels and a dip in pro-inflammatory Th17 immune cells due to ketone bodies production.

In Cell this week: strategy for prophylactic antiviral CRISPR in human cells; influence of obesity, genetics, and hormone signaling on pancreatic ductal adenocarcinoma; and more.

An analysis of biobank data from Japan, the UK, and Finland found the link between obesity and lifespan was stronger among individuals with European ancestry.

In PLOS this week: signs of selection on microRNA targets, HPV sequences as markers of cervical cancer, and more.

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The Wall Street Journal reports on gaps in COVID-19 testing affecting less affluent urban areas and rural locations.

According to NBC News, new SARS-CoV-2 variants are making it harder for researchers to model the course of the pandemic.

The New York Times reports that experts say President Joe Biden's goal of vaccinating 1 million people a day in the US in the next 100 days is too low a bar.

In Science this week: single-cell lineage tracing technique applied to study lung cancer metastasis, and more.