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In Science this week: 29 widespread antiviral gene cassettes uncovered, and more.

A Regeneron-led team identified four variants that affect LDL cholesterol levels and are much more prevalent among Southwestern American Indians.

Researchers found that diurnal gut microbe fluctuations are disrupted in individuals with type 2 diabetes, leading to a bacterial signature for risk profiling.

In PLOS this week: genome-wide association study of agronomic traits in sugarcane, breastfeeding can modulate body-mass index among individuals at genetic risk of obesity, and more.

Northern and southern Italians further developed what appear to be genetic adaptations affecting susceptibility to obesity and melanoma, respectively.

In animal models, loss of ALK was associated with protection from obesity, even when the animals were on a high-fat diet.

Researchers saw a shift toward lower gut bifidobacterial levels and a dip in pro-inflammatory Th17 immune cells due to ketone bodies production.

In Cell this week: strategy for prophylactic antiviral CRISPR in human cells; influence of obesity, genetics, and hormone signaling on pancreatic ductal adenocarcinoma; and more.

An analysis of biobank data from Japan, the UK, and Finland found the link between obesity and lifespan was stronger among individuals with European ancestry.

In PLOS this week: signs of selection on microRNA targets, HPV sequences as markers of cervical cancer, and more.

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Novavax has begun a phase III trial of its SARS-CoV-2 vaccine, according to the New York Times.

Vox reports that the Trump Administration may limit student visas for individuals from some countries to two years.

The governor of New York says the state will conduct its own review of any SARS-CoV-2 vaccine, NPR reports.

This week in Science: Neanderthal Y chromosomes replaced by Homo sapiens Y chromosomes, and more.