obesity
Blood-Based 'Omics Signatures Reflect 'Biological' BMI, Metabolic Health
Features found in the blood offered a more refined look at obesity and related conditions, shifting more readily than body mass index in response to lifestyle changes.
Female-Specific Fat Distribution Gene, Regulatory Variant Emerge from Gene Expression Study
With transcriptome-wide association studies of BMI and waist-to-hip ratio adjusted for BMI, researchers began to untangle the genetics of fat distribution.
Genetic Risk Score Helps Predict Severe Obesity Later in Life in Childhood Cancer Survivors
Risk prediction models picked up four times as many childhood cancer survivors prone to severe obesity in adulthood when genetic risk scores were included.
PreventionGenetics Nabs FDA Approval for Obesity Drug Companion Diagnostic
The test detects variants in the POMC, PCSK1, and LEPR genes to identify individuals eligible for treatment with Rhythm Pharmaceuticals' recently approved Imcivree.
Polygenic Risk Score Performance Improved With Expression-Related Rare Variant Insights
Using an independent outlier gene count score, investigators found that rare variants linked to gene expression outlier effects can improve polygenic risk score predictions.