neurodegenerative disease Engine Biosciences Using CRISPR, Machine Learning to Build Drug Candidate Pipeline Premium Fresh off a $43 million fundraising round, the drug discovery-focused bioinformatics firm is validating novel drug targets and compounds with an eye toward 2023 clinical trials. Valted Seq Lands Exclusive Rights to Evaluate Johns Hopkins Neurodegenerative Disease Dx Assays The biomarker assays could one day be used as companion diagnostics for new treatments of Parkinson's and related diseases. Alzheimer's Disease Genomes Lead to Novel Loci Involved in Synaptic Function Starting with genome sequences for thousands of individuals from Alzheimer's-affected families, researchers found rare disease-associated variants at 13 new loci. Neanderthal Gene Variant Alters Neurodevelopment in Human Brain Organoids Researchers used CRISPR to reintroduce an archaic variant of NOVA1 into cortical organoids to study how a human-specific variant may have affected evolution. Alzheimer's Disease Subtypes Proposed From Gene Expression Profiles of Brain Regions Investigators identified five expression subtypes spanning three broader clusters in postmortem parahippocampal gyrus samples from Alzheimer's patients. Jan 7, 2021 Genuity Science, Emory Team on Biomarker Discovery for Neurodegenesis Nov 9, 2020 Invitae, Passage Bio Collaborate on GM1 Genetic Testing, Clinical Trial Education May 21, 2020 PrecisionLife Pivots to In Silico Target Validation, COVID-19 Drug Repurposing Premium Jun 26, 2019 Quanterix to Acquire UmanDiagnostics for $22.5M Dec 5, 2018 Chan Zuckerberg Initiative Awards $52M in Grants for Neurodegenerative Disease Research Jul 16, 2018 Verge Genomics Scores $32M in Series A Round May 24, 2018 Cancer Increase Reported in Families With Tau Mutation-Associated Neurodegeneration Apr 9, 2018 Sporadic ALS Risk Appears to Overlap Slightly With Other Neurodegenerative Conditions Feb 9, 2018 Q-State Subsidiary Buys Claritas Assets, Plans Relaunch of Lab to Support Drug Discovery Programs Premium Jan 10, 2018 Crohn's, Parkinson's Diseases Share Risk Gene Dec 13, 2017 Berg, MGH, BWH, Collaborate on Neurodegenerative Disorder Biomarker Identification, Treatment Dec 7, 2017 New Giro Health Open Initiative Seeks Answers to Neurodegenerative Diseases Sep 28, 2016 Quanterix Invests in ImmunArray, Gains Access to Brain Injury Biomarker Portfolio May 23, 2016 Aurum Ventures Invests $1.2M in Hebrew U's Yissum for Circulating DNA Test Development Feb 3, 2016 Cofactor Genomics Acquires Narus Biotechnologies Jan 11, 2016 Diamir Inks Evaluation Deal with Janssen for microRNA Dx Technology Nov 5, 2015 Affymetrix, XRGenomics Collaborate on Dx for Age-Related Diseases Oct 28, 2015 Verge Genomics Raises $4M in Seed Financing Jun 25, 2015 Amprion Wins NIH Grant to Develop Alzheimer's Disease Diagnostic Premium Jan 13, 2015 Amarantus Acquires DioGenix for up to $10.9M Load More Breaking News SUPER Psychosis Study Presented at ASHG Digs Into Relationships of Rare Variants, Phenotypes People in the News: New Appointments at Myriad Genetics, Becton Dickinson, Delfi Diagnostics, More In Brief This Week: Virginia Commonwealth University, Dovetail Genomics, Lucid Diagnostics, and More New Products Posted to GenomeWeb: Bio-Rad, PerkinElmer, Ares Genetics, Purigen Biosystems, More Genetron Health, Fosun Ink Commercialization Deal for Seq-MRD Test in China MultiMuTHER Team Tracks Expression, Metabolite Relationships in Aging TwinsUK Participants The Scan More Boosters for US Following US Food and Drug Administration authorization, the Centers for Disease Control and Prevention has endorsed booster doses of the Moderna and Johnson & Johnson SARS-CoV-2 vaccines, the Washington Post writes. From a Pig A genetically modified pig kidney was transplanted into a human without triggering an immune response, Reuters reports. For Privacy's Sake Wired reports that more US states are passing genetic privacy laws. Science Paper on How Poaching Drove Evolution in African Elephants In Science this week: poaching has led to the rapid evolution of tuskless African elephants.