neurodegenerative disease Engine Biosciences Using CRISPR, Machine Learning to Build Drug Candidate Pipeline Premium Fresh off a $43 million fundraising round, the drug discovery-focused bioinformatics firm is validating novel drug targets and compounds with an eye toward 2023 clinical trials. Valted Seq Lands Exclusive Rights to Evaluate Johns Hopkins Neurodegenerative Disease Dx Assays The biomarker assays could one day be used as companion diagnostics for new treatments of Parkinson's and related diseases. Alzheimer's Disease Genomes Lead to Novel Loci Involved in Synaptic Function Starting with genome sequences for thousands of individuals from Alzheimer's-affected families, researchers found rare disease-associated variants at 13 new loci. Neanderthal Gene Variant Alters Neurodevelopment in Human Brain Organoids Researchers used CRISPR to reintroduce an archaic variant of NOVA1 into cortical organoids to study how a human-specific variant may have affected evolution. Alzheimer's Disease Subtypes Proposed From Gene Expression Profiles of Brain Regions Investigators identified five expression subtypes spanning three broader clusters in postmortem parahippocampal gyrus samples from Alzheimer's patients. Jan 7, 2021 Genuity Science, Emory Team on Biomarker Discovery for Neurodegenesis Nov 9, 2020 Invitae, Passage Bio Collaborate on GM1 Genetic Testing, Clinical Trial Education May 21, 2020 PrecisionLife Pivots to In Silico Target Validation, COVID-19 Drug Repurposing Premium Jun 26, 2019 Quanterix to Acquire UmanDiagnostics for $22.5M Dec 5, 2018 Chan Zuckerberg Initiative Awards $52M in Grants for Neurodegenerative Disease Research Jul 16, 2018 Verge Genomics Scores $32M in Series A Round May 24, 2018 Cancer Increase Reported in Families With Tau Mutation-Associated Neurodegeneration Apr 9, 2018 Sporadic ALS Risk Appears to Overlap Slightly With Other Neurodegenerative Conditions Feb 9, 2018 Q-State Subsidiary Buys Claritas Assets, Plans Relaunch of Lab to Support Drug Discovery Programs Premium Jan 10, 2018 Crohn's, Parkinson's Diseases Share Risk Gene Dec 13, 2017 Berg, MGH, BWH, Collaborate on Neurodegenerative Disorder Biomarker Identification, Treatment Dec 7, 2017 New Giro Health Open Initiative Seeks Answers to Neurodegenerative Diseases Sep 28, 2016 Quanterix Invests in ImmunArray, Gains Access to Brain Injury Biomarker Portfolio May 23, 2016 Aurum Ventures Invests $1.2M in Hebrew U's Yissum for Circulating DNA Test Development Feb 3, 2016 Cofactor Genomics Acquires Narus Biotechnologies Jan 11, 2016 Diamir Inks Evaluation Deal with Janssen for microRNA Dx Technology Nov 5, 2015 Affymetrix, XRGenomics Collaborate on Dx for Age-Related Diseases Oct 28, 2015 Verge Genomics Raises $4M in Seed Financing Jun 25, 2015 Amprion Wins NIH Grant to Develop Alzheimer's Disease Diagnostic Premium Jan 13, 2015 Amarantus Acquires DioGenix for up to $10.9M Load More Breaking News Roche Receives FDA EUA for PCR-Based, Point-of-Care SARS-CoV-2 Test Decode Study Identifies Proteomic Predictors of All-Cause Mortality In Brief This Week: Natera, Bruker, Bayer, and More New Products Posted to GenomeWeb: Labcorp, Omniseq, Dovetail Genomics, DNA Script, More People in the News: New Appointments at Sema4, Strata Oncology, Bionano Genomics, More Co-Diagnostics Gets CE Mark for Saliva-Based Molecular SARS-CoV-2 Test The Scan Billions for Antivirals The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports. NFT of the Web Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports. 23andMe on the Nasdaq 23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported. Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.