neuroblastoma
Pediatric Cancer Study Spells Out Structural Variant Risk Contributors
Researchers unearthed rare germline structural variants involved in pediatric solid tumor risk by analyzing genome sequences from patients, parents, and adult control individuals.
Olfactory Neuroblastoma Subtypes Spelled out in Single-Cell Sequencing Study
Researchers used single-cell RNA sequencing to cluster olfactory neuroblastoma tumors into neural, basal, and mesenchymal subtypes and find tumor microenvironment features.
Neuroblastoma Mutational Processes Uncovered by Whole-Genome Sequencing
Using matched tumor-normal genome sequencing, investigators discovered distinct mutational processes in three clusters of high-risk or non-high-risk neuroblastoma cases.
Neuroblastoma Outcomes Linked to Tumor Evolution Features, Timeframe
With deep genome sequencing and molecular clock analyses of 186 neuroblastomas, researchers saw ties between longer tumor evolution and more aggressive disease.
Peripheral Neuroblastic Tumor Transcriptomes Point to Transitional Cell State
Single-cell RNA sequencing data from malignant and nonmalignant cells revealed prognostically important signatures linked to more aggressive tumor forms.