neuroblastoma
Neuroblastoma Mutational Processes Uncovered by Whole-Genome Sequencing
Using matched tumor-normal genome sequencing, investigators discovered distinct mutational processes in three clusters of high-risk or non-high-risk neuroblastoma cases.
Neuroblastoma Outcomes Linked to Tumor Evolution Features, Timeframe
With deep genome sequencing and molecular clock analyses of 186 neuroblastomas, researchers saw ties between longer tumor evolution and more aggressive disease.
Peripheral Neuroblastic Tumor Transcriptomes Point to Transitional Cell State
Single-cell RNA sequencing data from malignant and nonmalignant cells revealed prognostically important signatures linked to more aggressive tumor forms.
Single-Cell Transcriptomic Analysis Traces Neuroblastomas to Developing Adrenal Neuroblasts
The analysis further found that low-risk tumors might develop from cells further along in development, while high-risk ones might develop from earlier-stage cells.
Childhood Cancer Study Reveals Pan-Neuroblastoma Cell State
The researchers said this unexpected homogeneity in the cellular identity of neuroblastoma could lead to the development of targeted treatments.