myocardial infarction

A spontaneous coronary condition that is overrepresented in young women had a polygenic risk score linked to lower-than-usual atherosclerosis-related heart disease risk.

The findings underscore the value of carrying out large-scale human genetic analyses as part of drug target identification and validation efforts. 

Researchers investigated how well four polygenic risk scores for coronary heart disease performed in three racial or ethnic groups in the US.

The company aims to repurpose drugs by translating the mechanisms that allow hibernating animals to withstand the stresses of extended sleep.

A European study, published today in NEJM, used a POC, PCR-based system to perform CYP2C19 genotyping to guide platelet inhibitor therapy.

UK and Swedish researchers used a Mendelian randomization approach to study the association between serum calcium and heart disease and heart attack risk.

By studying variants in PCSK9, researchers reported the therapies targeting the gene would have some of the same effects as statins.