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A spontaneous coronary condition that is overrepresented in young women had a polygenic risk score linked to lower-than-usual atherosclerosis-related heart disease risk.
The findings underscore the value of carrying out large-scale human genetic analyses as part of drug target identification and validation efforts.
Researchers investigated how well four polygenic risk scores for coronary heart disease performed in three racial or ethnic groups in the US.
The company aims to repurpose drugs by translating the mechanisms that allow hibernating animals to withstand the stresses of extended sleep.
A European study, published today in NEJM, used a POC, PCR-based system to perform CYP2C19 genotyping to guide platelet inhibitor therapy.
In PNAS this week: Cdx2 cells can help regenerate heart tissue in mice following a heart attack, PIWI-interacting small RNA levels in human cancer, and more.
A female mummy showing anatomical signs of atherosclerotic cardiovascular disease was found to carry risky versions of seven heart disease-related SNPs.
UK and Swedish researchers used a Mendelian randomization approach to study the association between serum calcium and heart disease and heart attack risk.
By studying variants in PCSK9, researchers reported the therapies targeting the gene would have some of the same effects as statins.
The Estonian Genome Center aims to introduce genomic medicine via the country's online medical data infrastructure, according to Andres Metspalu, its director.
Politico reports that the NYPD DNA database has grown since it announced it would be removing profiles from it.
Forbes reports that a structural biology lab at Oxford University studying the coronavirus was hacked.
Science reports that a Dutch research funding agency is combating a ransomware attack.
In Science this week: set of 64 haplotype assemblies from 32 individuals, and more.