Sudden Cardiac Death Risk Informed by Genome-Wide Polygenic Score for Heart Disease
In individuals with a history of coronary artery disease (CAD), a polygenic risk score for CAD showed promise for predicting the risk of sudden and/or arrhythmic death.
Myocardial Infarction Features Found With Multiomic Molecular Map
Using spatial transcriptomics, single-cell gene expression, and chromatin accessibility profiling, researchers retraced the consequences of myocardial infarction over time.
Complex Genetics Identified for Heart Condition Affecting Seemingly Healthy Young Women
A spontaneous coronary condition that is overrepresented in young women had a polygenic risk score linked to lower-than-usual atherosclerosis-related heart disease risk.
Genetic Study Explains Link Between Osteoporosis Drug, Cardiovascular Risk
The findings underscore the value of carrying out large-scale human genetic analyses as part of drug target identification and validation efforts.
Coronary Heart Disease Polygenic Risk Scores Differ in Utility Between Ethnic Groups
Researchers investigated how well four polygenic risk scores for coronary heart disease performed in three racial or ethnic groups in the US.